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Tbio
PPP1R16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

Protein Summary
Description
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). I ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299824
  • ENSP00000299824
  • ENSG00000101445
  • ENST00000373331
  • ENSP00000362428

Symbol
  • ANKRD4
  • KIAA0823
  • TIMAP
  • ANKRD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.85
transcription factor
0.74
kinase perturbation
0.71
transcription factor binding site profile
0.71
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.12   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.12   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
1
1.1
78
sex hormone-binding globulin measurement
2
1
2
76.5
self reported educational attainment
1
1
1
33.7
intelligence
1
1
1
33.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
78
sex hormone-binding globulin measurement
2
76.5
self reported educational attainment
1
33.7
intelligence
1
33.7
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Protein-Protein Interactions (30)
1 – 10 of 30
ZNF627
Tdark
Family: TF
Novelty: 0.34605017
p_int: 0.999996683
p_ni: 0.000001286
p_wrong: 0.000002032
Score: 0.258
Data Source: BioPlex,STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
p_int: 0.999991127
p_ni: 0.000008867
p_wrong: 6e-9
Score: 0.361
Data Source: BioPlex,STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.99982443
p_ni: 0.00017557
Score: 0.75
Data Source: BioPlex,STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999709732
p_ni: 0.000290268
Score: 0.84
Data Source: BioPlex,STRINGDB
PPP1CB
Tbio
Family: Enzyme
Novelty: 0.0122614
p_int: 0.998926515
p_ni: 0.001073485
Score: 0.944
Data Source: BioPlex,STRINGDB
ZNF564
Tdark
Family: TF
Novelty: 23
p_int: 0.995751366
p_ni: 4.8e-8
p_wrong: 0.004248586
Score: 0.344
Data Source: BioPlex,STRINGDB
PPP1R7
Tbio
Family: Enzyme
Novelty: 0.02088568
p_int: 0.930743866
p_ni: 0.069256134
Score: 0.845
Data Source: BioPlex,STRINGDB
PXDNL
Tbio
Novelty: 0.09498456
p_int: 0.869862058
p_ni: 0.13009954
p_wrong: 0.000038401
Score: 0.282
Data Source: BioPlex,STRINGDB
ZNF24
Tbio
Family: TF
Novelty: 0.02954446
p_int: 0.854908024
p_ni: 0.145091976
p_wrong: 1e-9
Score: 0.215
Data Source: BioPlex,STRINGDB
KLHL13
Tdark
Novelty: 0.23576387
p_int: 0.827611618
p_ni: 0.172388382
Score: 0.345
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  16.12

PubMed score by year
PubTator Score  8.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer