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Tbio
CDH16
Cadherin-16

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299752
  • ENSP00000299752
  • ENSG00000166589
  • ENST00000394055
  • ENSP00000377619
  • ENST00000565796
  • ENSP00000454784
  • ENST00000568632
  • ENSP00000455263
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
virus perturbation
0.64
disease perturbation
0.56
transcription factor
0.49
cell line
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.94   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 538   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.94   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 538   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
64.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
64.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin 16
VGNC:5708
454148
Macaque
cadherin 16
697166
Mouse
MGI:106671
12556
Rat
RGD:1311638
307614
Dog
cadherin 16
VGNC:39024
489770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin 16
Macaque
cadherin 16
Mouse
Rat
Dog
cadherin 16
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75309-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (120)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (44)
1 – 10 of 44
CDHR5
Tbio
Novelty: 0.08525208
Score: 0.673
Data Source: STRINGDB
PAX8
Tbio
Family: TF
Novelty: 0.0014232
Score: 0.668
Data Source: STRINGDB
SLC5A9
Tbio
Family: Transporter
Novelty: 0.10768341
Score: 0.62
Data Source: STRINGDB
CPO
Tdark
Family: Enzyme
Novelty: 0.28790034
Score: 0.569
Data Source: STRINGDB
DAB2IP
Tbio
Novelty: 0.01423445
Score: 0.567
Data Source: STRINGDB
SARS
Tbio
Family: Enzyme
Novelty: 0.00963508
Score: 0.566
Data Source: STRINGDB
WARS
Tbio
Family: Enzyme
Novelty: 0.00202764
Score: 0.563
Data Source: STRINGDB
LOXL2
Tbio
Family: Enzyme
Novelty: 0.00599536
Score: 0.523
Data Source: STRINGDB
LYPD3
Tbio
Novelty: 0.03248533
Score: 0.515
Data Source: STRINGDB
CTNNAL1
Tbio
Novelty: 0.03667606
Score: 0.512
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.94

PubMed score by year
PubTator Score  25.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer