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Tbio
HEATR3
HEAT repeat-containing protein 3

Protein Summary
Description
The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299192
  • ENSP00000299192
  • ENSG00000155393

Symbol
  • SYO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
virus perturbation
0.76
kinase perturbation
0.71
transcription factor binding site profile
0.69
interacting protein
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
83.9
1
1
0
1.2
83.9
2
1
0
1.2
64.5
1
1
0
1.2
60.7
1
1
0
1.1
55.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
83.9
0
1.2
83.9
0
1.2
64.5
0
1.2
60.7
0
1.1
55.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HEAT repeat containing 3
VGNC:5782
465159
Macaque
HEAT repeat containing 3
696428
Mouse
MGI:2444491
234549
Rat
RGD:1308267
361375
Dog
HEAT repeat containing 3
VGNC:41634
478132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HEAT repeat containing 3
Macaque
HEAT repeat containing 3
Mouse
Rat
Dog
HEAT repeat containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z4Q2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (116)
1 – 10 of 116
EXOG
Tbio
Family: Enzyme
Novelty: 0.03588463
p_int: 0.999998253
p_ni: 0.000001747
Data Source: BioPlex
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
p_int: 0.999986933
p_ni: 0.000013067
Data Source: BioPlex
DHRS2
Tbio
Family: Enzyme
Novelty: 0.002032
p_int: 0.999966067
p_ni: 0.00002285
p_wrong: 0.000011083
Data Source: BioPlex
RPL11
Tbio
Novelty: 0.00448962
p_int: 0.999251159
p_ni: 0.000748841
Score: 0.267
Data Source: BioPlex,STRINGDB
HIST1H1C
Tbio
Novelty: 0.00415337
p_int: 0.999190706
p_ni: 0.000809294
Data Source: BioPlex
SIGLECL1
Tdark
p_int: 0.998927695
p_ni: 0.001072305
Data Source: BioPlex
UXS1
Tbio
Family: Enzyme
Novelty: 0.04671281
p_int: 0.998710724
p_ni: 0.001289235
p_wrong: 4.2e-8
Data Source: BioPlex
SGPL1
Tchem
Family: Enzyme
Novelty: 0.00272574
p_int: 0.998637193
p_ni: 0.001362807
Data Source: BioPlex
TMEM206
Tdark
Novelty: 0.17311172
p_int: 0.998364052
p_ni: 0.001635948
Data Source: BioPlex
DPY19L1
Tdark
Family: Enzyme
Novelty: 0.34765717
p_int: 0.998057385
p_ni: 0.001940079
p_wrong: 0.000002535
Data Source: BioPlex
Publication Statistics
PubMed Score  12.55

PubMed score by year
PubTator Score  10.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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