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Tbio
CAPRIN2
Caprin-2

Protein Classes
Protein Summary
Description
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298892
  • ENSP00000298892
  • ENSG00000110888
  • ENST00000395805
  • ENSP00000379150
  • ENST00000417045
  • ENSP00000391479
  • ENST00000454014
  • ENSP00000403876

Symbol
  • C1QDC1
  • EEG1
  • KIAA1873
  • RNG140
  • EEG1
  • EEG-1
  • C1QDC1
  • RNG140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
histone modification site profile
0.87
biological process
0.84
transcription factor perturbation
0.84
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.68   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.68   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
78.7
waist-hip ratio
1
1
1
61.2
body height
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
78.7
waist-hip ratio
1
61.2
body height
1
8.3
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (29)
1 – 10 of 29
C1QTNF12
Tbio
Novelty: 0.0694377
Score: 0.737
Data Source: STRINGDB
VPS52
Tbio
Novelty: 0.01439614
Score: 0.645
Data Source: STRINGDB
SOX5
Tbio
Family: TF
Novelty: 0.00623121
Score: 0.535
Data Source: STRINGDB
DSEL
Tdark
Family: Enzyme
Novelty: 0.0885822
Score: 0.53
Data Source: STRINGDB
KLHL22
Tbio
Novelty: 0.24456252
Score: 0.53
Data Source: STRINGDB
CLTC
Tbio
Novelty: 0.00256674
Score: 0.528
Data Source: STRINGDB
RPL6
Tbio
Novelty: 0.01742007
Score: 0.504
Data Source: STRINGDB
LRP5
Tbio
Novelty: 0.00089807
Score: 0.496
Data Source: STRINGDB
FUBP1
Tbio
Novelty: 0.01745195
Score: 0.464
Data Source: STRINGDB
BICRA
Tbio
Novelty: 0.13482404
Score: 0.46
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.68

PubMed score by year
PubTator Score  18.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer