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Tbio
RAPSN
43 kDa receptor-associated protein of the synapse

Protein Summary
Description
Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298854
  • ENSP00000298854
  • ENSG00000165917
  • ENST00000352508
  • ENSP00000298853

Symbol
  • RNF205
  • FADS
  • CMS11
  • CMS4C
  • RAPSYN
  • RNF205
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.74
cellular component
0.68
kinase perturbation
0.6
phenotype
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.04   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.04   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
2
0
6.5
85
mean corpuscular hemoglobin concentration
1
1
1
80.3
unipolar depression
1
1
1
77.5
1
1
1
77.5
diastolic blood pressure
1
1
1
73.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
0
6.5
85
mean corpuscular hemoglobin concentration
1
80.3
unipolar depression
1
77.5
1
77.5
diastolic blood pressure
1
73.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor associated protein of the synapse
VGNC:3237
451705
Macaque
receptor associated protein of the synapse
711689
Mouse
MGI:99422
19400
Rat
RGD:1311592
362161
Dog
receptor associated protein of the synapse
VGNC:45350
609725
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor associated protein of the synapse
Macaque
receptor associated protein of the synapse
Mouse
Rat
Dog
receptor associated protein of the synapse
Protein-Protein Interactions (88)
1 – 10 of 88
MUSK
Tchem
Family: Kinase
Novelty: 0.00151518
Score: 0.997
Data Source: STRINGDB
AGRN
Tbio
Novelty: 0.00156441
Score: 0.985
Data Source: STRINGDB
CHRNB1
Tclin
Family: IC
Novelty: 0.04777051
Score: 0.983
Data Source: STRINGDB
CHRNA1
Tclin
Family: IC
Novelty: 0.01393364
Score: 0.974
Data Source: STRINGDB
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
Score: 0.969
Data Source: STRINGDB
CHRNG
Tclin
Family: IC
Novelty: 0.03295438
Score: 0.969
Data Source: STRINGDB
UTRN
Tbio
Novelty: 0.0018541
Score: 0.968
Data Source: STRINGDB
DMD
Tclin
Novelty: 0.00025661
Score: 0.956
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.923
Data Source: STRINGDB
LAMB2
Tbio
Novelty: 0.07966931
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  181.04

PubMed score by year
PubTator Score  129.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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