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Tbio
FRMD7
FERM domain-containing protein 7

Protein Summary
Description
Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. Mutations in this gene are associated with X-linked congenital nystagmus. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298542
  • ENSP00000298542
  • ENSG00000165694
  • ENST00000464296
  • ENSP00000417996

Symbol
  • NYS
  • NYS1
  • XIPAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
cell line
0.51
biological term
0.5
microRNA
0.42
chemical
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.48   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.48   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
25.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
25.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 7
VGNC:1384
473785
Macaque
FERM domain containing 7
705736
Mouse
MGI:2686379
385354
Rat
RGD:1562057
302826
Dog
FERM domain containing 7
VGNC:40984
492141
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 7
Macaque
FERM domain containing 7
Mouse
Rat
Dog
FERM domain containing 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZUT3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (37)
1 – 10 of 37
GPR143
Tbio
Family: GPCR
Novelty: 0.01507388
Score: 0.84
Data Source: STRINGDB
CASK
Tchem
Family: Kinase
Novelty: 0.00856437
Score: 0.808
Data Source: STRINGDB
CRYZL1
Tbio
Family: Enzyme
Novelty: 0.04435286
Score: 0.759
Data Source: STRINGDB
NYX
Tbio
Novelty: 0.0100148
Score: 0.757
Data Source: STRINGDB
CDR1
Tbio
Novelty: 0.00142118
Score: 0.715
Data Source: STRINGDB
MSLNL
Tdark
Novelty: 0.34037333
Score: 0.715
Data Source: STRINGDB
OPN1MW2
Tdark
Novelty: 0.00822178
Score: 0.71
Data Source: STRINGDB
ARHGDIA
Tchem
Novelty: 0.001991
Score: 0.696
Data Source: STRINGDB
SLC25A14
Tbio
Family: Transporter
Novelty: 0.02268116
Score: 0.649
Data Source: STRINGDB
OPN1LW
Tbio
Family: GPCR
Novelty: 0.00323065
Score: 0.648
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.48

PubMed score by year
PubTator Score  60.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer