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Tbio
VEGFD
Vascular endothelial growth factor D

Protein Summary
Description
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297904
  • ENSP00000297904
  • ENSG00000165197

Symbol
  • FIGF
  • FIGF
  • VEGF-D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.3   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 593   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.3   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 593   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor D measurement
1
1
0
1.6
73.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor D measurement
0
1.6
73.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Signal Transduction
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (146)
1 – 10 of 146
ADAM9
Tchem
Family: Enzyme
Novelty: 0.00616626
p_int: 0.994234793
p_ni: 0.005765193
p_wrong: 1.4e-8
Score: 0.225
Data Source: BioPlex,STRINGDB
UBR4
Tbio
Family: Enzyme
Novelty: 0.03924839
p_int: 0.966958496
p_ni: 0.033041504
Score: 0.638
Data Source: BioPlex,STRINGDB
BIRC6
Tbio
Novelty: 0.01187953
p_int: 0.858658686
p_ni: 0.141341314
Score: 0.189
Data Source: BioPlex,STRINGDB
KCMF1
Tbio
Family: Enzyme
Novelty: 0.05485534
p_int: 0.826729383
p_ni: 0.1732146
p_wrong: 0.000056017
Score: 0.892
Data Source: BioPlex,STRINGDB
FLT4
Tclin
Family: Kinase
Novelty: 0.001296
Score: 0.997
Data Source: Reactome,STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.995
Data Source: Reactome,STRINGDB
THBS1
Tbio
Novelty: 0.00073905
Score: 0.961
Data Source: STRINGDB
HGF
Tchem
Family: Enzyme
Novelty: 0.00035574
Score: 0.952
Data Source: STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.949
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.946
Data Source: STRINGDB
Publication Statistics
PubMed Score  400.30

PubMed score by year
PubTator Score  293.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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