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Tbio
TMC1
Transmembrane channel-like protein 1

Protein Summary
Description
Probable ion channel required for the normal function of cochlear hair cells. This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297784
  • ENSP00000297784
  • ENSG00000165091
  • ENST00000340019
  • ENSP00000341433
  • ENST00000645208
  • ENSP00000494684

Symbol
  • DFNB7
  • DFNA36
  • DFNB11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
interacting protein
0.69
cell line
0.51
phenotype
0.5
tissue
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.97   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.97   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
68
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane channel like 1
VGNC:8942
472952
Macaque
transmembrane channel like 1
704827
Mouse
MGI:2151016
13409
Dog
transmembrane channel like 1
VGNC:47420
484168
Cow
transmembrane channel like 1
VGNC:35917
538406
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane channel like 1
Macaque
transmembrane channel like 1
Mouse
Dog
transmembrane channel like 1
Cow
transmembrane channel like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TDI8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (77)
1 – 10 of 77
TMIE
Tbio
Novelty: 0.02939225
Score: 0.921
Data Source: STRINGDB
LHFPL5
Tbio
Novelty: 0.03689538
Score: 0.859
Data Source: STRINGDB
PCDH15
Tbio
Novelty: 0.0097699
Score: 0.816
Data Source: STRINGDB
CDH23
Tbio
Novelty: 0.00588227
Score: 0.815
Data Source: STRINGDB
MYO15A
Tbio
Novelty: 0.0148787
Score: 0.806
Data Source: STRINGDB
OTOF
Tbio
Novelty: 0.00676341
Score: 0.795
Data Source: STRINGDB
TJP2
Tbio
Novelty: 0.00446681
Score: 0.757
Data Source: STRINGDB
FAM189A2
Tdark
Novelty: 0.41335428
Score: 0.748
Data Source: STRINGDB
SLC26A4
Tbio
Family: Transporter
Novelty: 0.00162006
Score: 0.745
Data Source: STRINGDB
GJB2
Tbio
Novelty: 0.00056398
Score: 0.741
Data Source: STRINGDB
Publication Statistics
PubMed Score  189.97

PubMed score by year
PubTator Score  116.23

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer