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Tbio
AP5Z1
AP-5 complex subunit zeta-1

Protein Summary
Description
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348624
  • ENSP00000297562
  • ENSG00000242802
  • ENST00000648925
  • ENSP00000496830
  • ENST00000649063
  • ENSP00000497815

Symbol
  • KIAA0415
  • SPG48
  • zeta
  • SPG48
  • KIAA0415
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor perturbation
0.74
transcription factor binding site profile
0.72
tissue sample
0.64
cell line
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental longevity
1
1
1
37.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental longevity
1
37.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 5 subunit zeta 1
VGNC:7213
472273
Macaque
adaptor related protein complex 5 zeta 1 subunit
715686
Mouse
MGI:1924908
231855
Dog
adaptor related protein complex 5 subunit zeta 1
VGNC:37973
609375
Horse
adaptor related protein complex 5 subunit zeta 1
VGNC:15394
100060677
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 5 subunit zeta 1
Macaque
adaptor related protein complex 5 zeta 1 subunit
Mouse
Dog
adaptor related protein complex 5 subunit zeta 1
Horse
adaptor related protein complex 5 subunit zeta 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43299-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (80)
1 – 10 of 80
SPG11
Tbio
Novelty: 0.00697875
p_int: 0.999999915
p_ni: 8.4e-8
p_wrong: 1e-9
Score: 0.946
Data Source: BioPlex,STRINGDB
SAYSD1
Tdark
Novelty: 0.62764863
p_int: 0.999479099
p_ni: 0.000520879
p_wrong: 2.2e-8
Data Source: BioPlex
LYPD4
Tbio
Novelty: 0.00381728
p_int: 0.886524656
p_ni: 0.00273263
p_wrong: 0.110742715
Score: 0.187
Data Source: BioPlex,STRINGDB
AP5S1
Tdark
Novelty: 1.92515745
Score: 0.991
Data Source: STRINGDB
AP5B1
Tdark
Novelty: 0.06116142
Score: 0.99
Data Source: STRINGDB
AP5M1
Tbio
Novelty: 0.00684623
Score: 0.982
Data Source: STRINGDB
AP4S1
Tdark
Novelty: 0.1142558
Score: 0.959
Data Source: STRINGDB
AP4E1
Tdark
Novelty: 0.09773225
Score: 0.957
Data Source: STRINGDB
AP4B1
Tbio
Novelty: 0.08255831
Score: 0.956
Data Source: STRINGDB
AP4M1
Tbio
Novelty: 0.00142961
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.25

PubMed score by year
PubTator Score  7.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer