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Tchem
SHH
Sonic hedgehog protein

Protein Summary
Description
Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). Sonic hedgehog protein N-product: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:24863049). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297261
  • ENSP00000297261
  • ENSG00000164690

Symbol
  • TPT
  • HHG1
  • HLP3
  • HPE3
  • SMMCI
  • ShhNC
  • TPTPS
  • MCOPCB5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
protein domain
0.97
phenotype
0.75
molecular function
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3983.46   (req: < 5)
Gene RIFs: 424   (req: <= 3)
Antibodies: 529   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3983.46   (req: >= 5)
Gene RIFs: 424   (req: > 3)
Antibodies: 529   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 147
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
vismodegib
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
3
3
8.3
67.5
systolic blood pressure
1
1
1
4.5
creatinine measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
8.3
67.5
systolic blood pressure
1
4.5
creatinine measurement
1
0.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sonic hedgehog
716553
Mouse
MGI:98297
20423
Rat
RGD:3673
29499
Dog
sonic hedgehog
VGNC:46147
608860
Cow
sonic hedgehog
VGNC:34597
286821
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sonic hedgehog
Mouse
Rat
Dog
sonic hedgehog
Cow
sonic hedgehog
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15465-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (77)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Activation of SMO
Class B/2 (Secretin family receptors)
Disease
Diseases of signal transduction
GPCR ligand binding
Gene Ontology Terms (155)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (586)
1 – 10 of 586
PTCH1
Tbio
Novelty: 0.00077635
Score: 0.999
Data Source: Reactome,STRINGDB
HHIP
Tbio
Novelty: 0.00982404
Score: 0.998
Data Source: Reactome,STRINGDB
GLI2
Tchem
Family: TF
Novelty: 0.00229126
Score: 0.996
Data Source: STRINGDB
PTCH2
Tbio
Novelty: 0.00927849
Score: 0.992
Data Source: STRINGDB
SMO
Tclin
Family: GPCR
Novelty: 0.03235855
Score: 0.989
Data Source: STRINGDB
GPC3
Tbio
Novelty: 0.00151823
Score: 0.989
Data Source: STRINGDB
GAS1
Tbio
Novelty: 0.00423304
Score: 0.987
Data Source: Reactome,STRINGDB
DISP1
Tbio
Novelty: 0.04770784
Score: 0.984
Data Source: STRINGDB
GLI1
Tchem
Family: TF
Novelty: 0.00077281
Score: 0.978
Data Source: STRINGDB
HHAT
Tbio
Family: Enzyme
Novelty: 0.003077
Score: 0.975
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  3983.46

PubMed score by year
PubTator Score  1269.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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