You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NEUROD6
Neurogenic differentiation factor 6

Protein Summary
Description
Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity). This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297142
  • ENSP00000297142
  • ENSG00000164600

Symbol
  • ATOH2
  • BHLHA2
  • Nex1
  • Atoh2
  • MATH2
  • NEX1M
  • Math-2
  • bHLHa2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
gene perturbation
0.68
cell type or tissue
0.61
biological process
0.56
cell line
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.33   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.33   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal tail volume
1
1
0
12.5
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal tail volume
0
12.5
5.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuronal differentiation 6
VGNC:4442
463333
Macaque
neuronal differentiation 6
694337
Mouse
MGI:106593
11922
Rat
RGD:1562793
500137
Dog
neuronal differentiation 6
VGNC:43755
482387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuronal differentiation 6
Macaque
neuronal differentiation 6
Mouse
Rat
Dog
neuronal differentiation 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96NK8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (105)
1 – 10 of 105
TBR1
Tbio
Family: TF
Novelty: 0.00676736
Score: 0.693
Data Source: STRINGDB
C1QL3
Tbio
Novelty: 0.06478495
Score: 0.676
Data Source: STRINGDB
CTDSPL
Tbio
Family: Enzyme
Novelty: 0.00471423
Score: 0.643
Data Source: STRINGDB
RSPO2
Tbio
Novelty: 0.0188211
Score: 0.599
Data Source: STRINGDB
GSTO1
Tchem
Family: Enzyme
Novelty: 0.00800915
Score: 0.593
Data Source: STRINGDB
SNCB
Tbio
Novelty: 0.00743454
Score: 0.592
Data Source: STRINGDB
GABRG2
Tclin
Family: IC
Novelty: 0.00819163
Score: 0.59
Data Source: STRINGDB
RBFOX1
Tbio
Novelty: 0.00571285
Score: 0.582
Data Source: STRINGDB
SATB2
Tbio
Family: TF
Novelty: 0.00405935
Score: 0.58
Data Source: STRINGDB
GABRA6
Tclin
Family: IC
Novelty: 0.02894664
Score: 0.58
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.33

PubMed score by year
PubTator Score  31.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer