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Tdark
MYOZ3
Myozenin-3

Protein Summary
Description
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. The protein encoded by this gene is specifically expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297130
  • ENSP00000297130
  • ENSG00000164591
  • ENST00000517768
  • ENSP00000428815
  • ENST00000615557
  • ENSP00000478375

Symbol
  • FRP3
  • CS3
  • CS-3
  • FRP3
  • FATZ-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.65
small molecule perturbation
0.64
tissue sample
0.59
cell line
0.52
microRNA
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myozenin 3
VGNC:13551
742850
Macaque
myozenin 3
712647
Mouse
MGI:2179296
170947
Dog
myozenin 3
VGNC:43585
610340
Horse
myozenin 3
VGNC:20523
100060280
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myozenin 3
Macaque
myozenin 3
Mouse
Dog
myozenin 3
Horse
myozenin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TDC0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (21)
1 – 10 of 21
LDB3
Tbio
Novelty: 0.01178009
Score: 0.872
Data Source: STRINGDB
FLNC
Tbio
Novelty: 0.00463205
Score: 0.816
Data Source: STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.815
Data Source: STRINGDB
TCAP
Tbio
Novelty: 0.00623581
Score: 0.781
Data Source: STRINGDB
ACTN1
Tbio
Novelty: 0.00654004
Score: 0.77
Data Source: STRINGDB
SYNPO
Tbio
Novelty: 0.00461054
Score: 0.647
Data Source: STRINGDB
MAPKAPK3
Tchem
Family: Kinase
Novelty: 0.02469147
Score: 0.595
Data Source: STRINGDB
MYOT
Tbio
Novelty: 0.00888671
Score: 0.53
Data Source: STRINGDB
RBM22
Tbio
Novelty: 0.0536968
Score: 0.501
Data Source: STRINGDB
MYBPC2
Tbio
Novelty: 0.12558067
Score: 0.497
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.14

PubMed score by year
PubTator Score  128.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer