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Tbio
HIST1H2AA
Histone H2A type 1-A

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297012
  • ENSP00000297012
  • ENSG00000164508

Symbol
  • H2AFR
  • H2AA
  • TH2A
  • H2AFR
  • bA317E16.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.79
cellular component
0.64
cell type or tissue
0.54
cell line
0.49
tissue
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.16   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.16   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H2A family member a
VGNC:14358
462486
Dog
histone cluster 1, H2aa
488251
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H2A family member a
Dog
histone cluster 1, H2aa
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96QV6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
HDACs deacetylate histones
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (190)
1 – 10 of 190
HIST1H2BA
Tbio
Novelty: 0.02431803
Score: 0.998
Data Source: STRINGDB
HIST1H2BB
Tbio
Novelty: 0.20192804
Score: 0.987
Data Source: STRINGDB
H2AFJ
Tbio
Novelty: 0.34726304
Score: 0.979
Data Source: STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
Score: 0.979
Data Source: STRINGDB
HIST2H2AB
Tbio
Novelty: 0.06772132
Score: 0.978
Data Source: STRINGDB
HIST2H2BE
Tbio
Novelty: 0.00024381
Score: 0.974
Data Source: STRINGDB
HIST1H2BN
Tbio
Novelty: 0.02592521
Score: 0.974
Data Source: STRINGDB
HIST3H2A
Tbio
Novelty: 0.34036249
Score: 0.973
Data Source: STRINGDB
KDM1A
Tchem
Family: Epigenetic
Novelty: 0.00142673
Score: 0.973
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.16

PubMed score by year
PubTator Score  2.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer