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Tbio
TLR3
Toll-like receptor 3

Protein Summary
Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundan ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296795
  • ENSP00000296795
  • ENSG00000164342
  • ENST00000504367
  • ENSP00000423684

Symbol
  • CD283
  • IIAE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
1
protein domain
0.85
histone modification site profile
0.82
biological term
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1772.74   (req: < 5)
Gene RIFs: 518   (req: <= 3)
Antibodies: 1071   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1772.74   (req: >= 5)
Gene RIFs: 518   (req: > 3)
Antibodies: 1071   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
1
0
1.1
47.1
Thyroid preparation use measurement
1
1
1
46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.1
47.1
Thyroid preparation use measurement
1
46
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (198)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

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Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Disease
Reactome
Diseases associated with the TLR signaling cascade
Reactome
Diseases of Immune System
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Disease
Diseases associated with the TLR signaling cascade
Diseases of Immune System
Immune System
Protein-Protein Interactions (403)
1 – 10 of 403
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.999
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.999
Data Source: Reactome,STRINGDB
TAB2
Tbio
Family: Enzyme
Novelty: 0.00635786
Score: 0.999
Data Source: Reactome,STRINGDB
TICAM1
Tbio
Novelty: 0.01058005
Score: 0.998
Data Source: Reactome,STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.997
Data Source: STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.994
Data Source: Reactome,STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.994
Data Source: STRINGDB
RIPK1
Tchem
Family: Kinase
Novelty: 0.00230565
Score: 0.993
Data Source: Reactome,STRINGDB
UNC93B1
Tbio
Novelty: 0.01288921
Score: 0.99
Data Source: Reactome,STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.989
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1772.74

PubMed score by year
PubTator Score  1121.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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