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Tbio
ENPP6
Ectonucleotide pyrophosphatase/phosphodiesterase family member 6

Protein Summary
Description
Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296741
  • ENSP00000296741
  • ENSG00000164303

Symbol
  • NPP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
protein domain
0.73
phenotype
0.63
cell type or tissue
0.57
microRNA
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.56   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.56   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
1
1
0
11.6
22.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
0
11.6
22.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectonucleotide pyrophosphatase/phosphodiesterase 6
VGNC:6422
461627
Macaque
ectonucleotide pyrophosphatase/phosphodiesterase 6
693950
Mouse
MGI:2445171
320981
Rat
RGD:1311645
306460
Dog
ectonucleotide pyrophosphatase/phosphodiesterase 6
VGNC:40377
475636
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectonucleotide pyrophosphatase/phosphodiesterase 6
Macaque
ectonucleotide pyrophosphatase/phosphodiesterase 6
Mouse
Rat
Dog
ectonucleotide pyrophosphatase/phosphodiesterase 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UWR7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Glycerophospholipid catabolism (R-HSA-6814848)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid catabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid catabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Protein-Protein Interactions (76)
1 – 10 of 76
CRLF3
Tbio
Novelty: 0.17318857
p_int: 0.99999975
p_ni: 1.1e-8
p_wrong: 2.38e-7
Score: 0.213
Data Source: BioPlex,STRINGDB
SACS
Tbio
Novelty: 0.00443197
p_int: 0.999996343
p_ni: 0.000003653
p_wrong: 4e-9
Score: 0.213
Data Source: BioPlex,STRINGDB
DIAPH3
Tbio
Novelty: 0.01165283
p_int: 0.99999516
p_ni: 0.000004837
p_wrong: 3e-9
Data Source: BioPlex
RUNDC1
Tdark
Novelty: 1.23644681
p_int: 0.999988289
p_ni: 0.000011704
p_wrong: 6e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
MEX3B
Tbio
Novelty: 0.14914846
p_int: 0.999971862
p_ni: 1.19e-7
p_wrong: 0.000028018
Score: 0.213
Data Source: BioPlex,STRINGDB
SCAMP1
Tbio
Novelty: 0.03293648
p_int: 0.999944433
p_ni: 0.000055567
Score: 0.156
Data Source: BioPlex,STRINGDB
MT-ND5
Tclin
Family: Enzyme
Novelty: 0.00223164
p_int: 0.996626249
p_ni: 0.003373746
p_wrong: 5e-9
Data Source: BioPlex
GNPAT
Tchem
Family: Enzyme
Novelty: 0.01255689
p_int: 0.996140152
p_ni: 0.003859848
p_wrong: 1e-9
Data Source: BioPlex
NDUFB8
Tclin
Family: Enzyme
Novelty: 0.019021
p_int: 0.99327048
p_ni: 0.006729515
p_wrong: 6e-9
Data Source: BioPlex
ZBTB33
Tbio
Family: TF
Novelty: 0.01327474
p_int: 0.991678016
p_ni: 0.008321984
Data Source: BioPlex
Publication Statistics
PubMed Score  14.56

PubMed score by year
PubTator Score  8.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer