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Tbio
NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

Protein Summary
Description
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296543
  • ENSP00000296543
  • ENSG00000164134

Symbol
  • GA19
  • NARG1
  • NATH
  • TBDN100
  • Ga19
  • NATH
  • TBDN
  • MRD50
  • NARG1
  • NAT1P
  • TBDN100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
transcription factor binding site profile
0.78
microRNA
0.77
tissue
0.74
protein domain
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.92   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.92   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
461495
Macaque
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
697123
Mouse
MGI:1922088
74838
Rat
RGD:1310984
310399
Dog
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
VGNC:54810
483817
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Macaque
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Mouse
Rat
Dog
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BXJ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (92)
1 – 10 of 92
NAA16
Tbio
Family: Enzyme
Novelty: 0.23261397
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
HYPK
Tbio
Novelty: 0.085555
p_int: 0.999999962
p_ni: 3.8e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
NAA50
Tbio
Family: Enzyme
Novelty: 0.01843508
p_int: 0.999999883
p_ni: 1.17e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
NAA10
Tbio
Family: Enzyme
Novelty: 0.00086809
p_int: 0.999984236
p_ni: 0.000015765
Score: 0.999
Data Source: BioPlex,STRINGDB
ARRB2
Tbio
Novelty: 0.00148149
p_int: 0.999933599
p_ni: 0.000066401
Data Source: BioPlex
BTF3
Tbio
Novelty: 0.01198537
p_int: 0.999238814
p_ni: 0.000761183
p_wrong: 3e-9
Score: 0.272
Data Source: BioPlex,STRINGDB
UBD
Tbio
Novelty: 0.00657227
p_int: 0.999172454
p_ni: 0.000827545
p_wrong: 1e-9
Data Source: BioPlex
TRAFD1
Tbio
Novelty: 0.144593
p_int: 0.9990725
p_ni: 0.0009275
Score: 0.189
Data Source: BioPlex,STRINGDB
FGB
Tbio
Novelty: 0.00437751
p_int: 0.99894731
p_ni: 0.001052687
p_wrong: 3e-9
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.998680986
p_ni: 0.001319014
Score: 0.162
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  188.92

PubMed score by year
PubTator Score  127.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer