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Tbio
H2AFZ
Histone H2A.Z

Protein Summary
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296417
  • ENSP00000296417
  • ENSG00000164032

Symbol
  • H2AZ
  • H2AZ
  • H2A.z
  • H2A/z
  • H2A.Z-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.98
kinase perturbation
0.98
molecular function
0.95
virus perturbation
0.92


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.76   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 466   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.76   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 466   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H2A histone family, member Z
461400
Macaque
H2A histone family, member Z
709326
Mouse
MGI:1888388
51788
Rat
RGD:621464
58940
Dog
H2A histone family, member Z
478493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H2A histone family, member Z
Macaque
H2A histone family, member Z
Mouse
Rat
Dog
H2A histone family, member Z
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P0C0S5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (84)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 73
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (615)
1 – 10 of 615
HIST1H2BO
Tdark
Novelty: 0.3427419
p_int: 0.999999977
p_ni: 2.2e-8
Score: 0.959
Data Source: BioPlex,STRINGDB
VPS72
Tbio
Novelty: 0.00561093
p_int: 0.999999971
p_ni: 2.3e-8
p_wrong: 6e-9
Score: 0.953
Data Source: BioPlex,STRINGDB
MIER3
Tdark
Family: TF
Novelty: 0.42079723
p_int: 0.999999958
p_ni: 4.2e-8
Score: 0.277
Data Source: BioPlex,STRINGDB
PHF14
Tbio
Family: Epigenetic
Novelty: 0.13279118
p_int: 0.999999857
p_ni: 1.43e-7
Score: 0.343
Data Source: BioPlex,STRINGDB
HIST1H2BD
Tbio
Novelty: 0.05094332
p_int: 0.999999799
p_ni: 1.5e-8
p_wrong: 1.87e-7
Score: 0.958
Data Source: BioPlex,STRINGDB
MIER1
Tbio
Novelty: 0.00357772
p_int: 0.999999672
p_ni: 3.28e-7
Score: 0.277
Data Source: BioPlex,STRINGDB
EPC2
Tbio
Novelty: 0.02760809
p_int: 0.999999306
p_ni: 6.94e-7
Score: 0.283
Data Source: BioPlex,STRINGDB
RAI1
Tbio
Family: Epigenetic
Novelty: 0.01088494
p_int: 0.999998964
p_ni: 0.000001035
p_wrong: 2e-9
Score: 0.312
Data Source: BioPlex,STRINGDB
ARID5B
Tbio
Family: TF
Novelty: 0.01201607
p_int: 0.999998383
p_ni: 0.000001611
p_wrong: 6e-9
Data Source: BioPlex
ACTR6
Tbio
Novelty: 0.11005766
p_int: 0.999998256
p_ni: 0.000001744
Score: 0.858
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  517.76

PubMed score by year
PubTator Score  212.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer