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Tbio
RHO
Rhodopsin

Protein Summary
Description
Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343). The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296271
  • ENSP00000296271
  • ENSG00000163914

Symbol
  • OPN2
  • RP4
  • OPN2
  • CSNBAD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.79
cell type or tissue
0.74
molecular function
0.73
biological term
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6393.34   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 492   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6393.34   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Activation of the phototransduction cascade (R-HSA-2485179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
Cargo trafficking to the periciliary membrane
Cilium Assembly
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Protein-Protein Interactions (293)
1 – 10 of 293
SAG
Tbio
Novelty: 0.00044383
Score: 0.999
Data Source: Reactome,STRINGDB
GRK1
Tchem
Family: Kinase
Novelty: 0.00931246
Score: 0.999
Data Source: Reactome,STRINGDB
GNB1
Tbio
Novelty: 0.04716243
Score: 0.996
Data Source: Reactome,STRINGDB
GRK7
Tchem
Family: Kinase
Novelty: 0.01412176
Score: 0.996
Data Source: Reactome,STRINGDB
RCVRN
Tbio
Novelty: 0.00332993
Score: 0.991
Data Source: STRINGDB
GNAT1
Tbio
Novelty: 0.03296558
Score: 0.991
Data Source: Reactome,STRINGDB
GNAT2
Tbio
Novelty: 0.02455598
Score: 0.99
Data Source: Reactome,STRINGDB
GNG2
Tbio
Novelty: 0.08273543
Score: 0.988
Data Source: Reactome,STRINGDB
GNB3
Tbio
Novelty: 0.0043523
Score: 0.978
Data Source: STRINGDB
ARF4
Tbio
Family: Enzyme
Novelty: 0.02098758
Score: 0.976
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  6393.34

PubMed score by year
PubTator Score  3931.88

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRT
1-70
PLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVC
70-140
KPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVV
140-210
HFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQG
210-280
SNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA
280-348
MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA