Tbio RHO Rhodopsin

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Rhodopsin

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Rhodopsin

Protein Summary

Description

Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343). The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P08100
• Q16414
• Q2M249

Gene Name

• RHO

Ensembl ID

• ENST00000296271
• ENSP00000296271
• ENSG00000163914

Symbol

• OPN2
• RP4
• OPN2
• CSNBAD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
gene perturbation	0.79
cell type or tissue	0.74
molecular function	0.73
biological term	0.72

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6393.34   (req: < 5)

Gene RIFs: 127   (req: <= 3)

Antibodies: 492   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6393.34   (req: >= 5)

Gene RIFs: 127   (req: > 3)

Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (23)

Reactome (16)

KEGG (1)

PathwayCommons (2)

WikiPathways (4)

Activation of the phototransduction cascade (R-HSA-2485179)

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Items per page:

5

1 – 5 of 16

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of the phototransduction cascade	11 targets	R-HSA-2485179
Reactome	Cargo trafficking to the periciliary membrane	51 targets	R-HSA-5620920
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594

Name	Explore in Pharos	Explore in Source
Activation of the phototransduction cascade	11 targets	R-HSA-2485179
Cargo trafficking to the periciliary membrane	51 targets	R-HSA-5620920
Cilium Assembly	187 targets	R-HSA-5617833
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594

Gene Ontology Terms (30)

Functions (4)

Components (13)

Processes (13)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
11-cis retinal binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
G protein-coupled photoreceptor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
G protein-coupled receptor activity	Traceable Author Statement (TAS)	ProtInc
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (293)

Explore Interacting Targets

1 – 10 of 293

• See Interactions on String-DB

SAG

Tbio

Novelty: 0.00044383

Score: 0.999

Data Source: Reactome,STRINGDB

GRK1

Tchem

Family: Kinase

Novelty: 0.00931246

Score: 0.999

Data Source: Reactome,STRINGDB

GNB1

Tbio

Novelty: 0.04716243

Score: 0.996

Data Source: Reactome,STRINGDB

GRK7

Tchem

Family: Kinase

Novelty: 0.01412176

Score: 0.996

Data Source: Reactome,STRINGDB

RCVRN

Tbio

Novelty: 0.00332993

Score: 0.991

Data Source: STRINGDB

GNAT1

Tbio

Novelty: 0.03296558

Score: 0.991

Data Source: Reactome,STRINGDB

GNAT2

Tbio

Novelty: 0.02455598

Score: 0.99

Data Source: Reactome,STRINGDB

GNG2

Tbio

Novelty: 0.08273543

Score: 0.988

Data Source: Reactome,STRINGDB

GNB3

Tbio

Novelty: 0.0043523

Score: 0.978

Data Source: STRINGDB

ARF4

Tbio

Family: Enzyme

Novelty: 0.02098758

Score: 0.976

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  6393.34

PubMed score by year

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PubTator Score  3931.88

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRT

1-70

PLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVC

70-140

KPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVV

140-210

HFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQG

210-280

SNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA

280-348

MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Cell projection
Chromophore
Complete proteome
Congenital stationary night blindness
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein