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Tbio
LZTFL1
Leucine zipper transcription factor-like protein 1

Protein Summary
Description
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function. This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296135
  • ENSP00000296135
  • ENSG00000163818
  • ENST00000536047
  • ENSP00000439522
  • ENST00000539217
  • ENSP00000441784

Symbol
  • BBS17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.85
disease perturbation
0.68
transcription factor binding site profile
0.61
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
3
2
0
1.8
97.7
Oral ulcer
1
1
0
1
84.4
macrophage inflammatory protein 1b measurement
1
1
1
81.2
C-X-C motif chemokine 16 measurement
1
1
1
58.5
eosinophil percentage of leukocytes
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
0
1.8
97.7
Oral ulcer
0
1
84.4
macrophage inflammatory protein 1b measurement
1
81.2
C-X-C motif chemokine 16 measurement
1
58.5
eosinophil percentage of leukocytes
1
8.5
Pathways (6)
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (38)
1 – 10 of 38
BBS5
Tbio
Novelty: 0.04208041
p_int: 0.999998538
p_ni: 0.000001462
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
BBS9
Tbio
Novelty: 0.01879869
p_int: 0.999995047
p_ni: 0.000004953
Score: 0.997
Data Source: BioPlex,STRINGDB
BBS4
Tbio
Novelty: 0.01825873
p_int: 0.999994539
p_ni: 0.000005402
p_wrong: 5.9e-8
Score: 0.993
Data Source: BioPlex,STRINGDB
TTC8
Tbio
Novelty: 0.08520636
p_int: 0.99992596
p_ni: 0.00007404
Score: 0.996
Data Source: BioPlex,STRINGDB
BBS2
Tbio
Novelty: 0.00835161
p_int: 0.998370303
p_ni: 0.001629697
Score: 0.996
Data Source: BioPlex,STRINGDB
BBS7
Tbio
Novelty: 0.03611111
p_int: 0.988237581
p_ni: 0.011762418
p_wrong: 1e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
BBS1
Tbio
Novelty: 0.00939439
p_int: 0.982684677
p_ni: 0.017315323
Score: 0.996
Data Source: BioPlex,STRINGDB
CEP250
Tbio
Novelty: 0.08014712
p_int: 0.951495929
p_ni: 0.048504071
Score: 0.196
Data Source: BioPlex,STRINGDB
TMEM38A
Tbio
Family: IC
Novelty: 0.10891929
p_int: 0.813062704
p_ni: 0.186937296
Score: 0.239
Data Source: BioPlex,STRINGDB
BBIP1
Tdark
Novelty: 0.23840637
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.36

PubMed score by year
PubTator Score  9.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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