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Tbio
PPBP
Platelet basic protein

Protein Summary
Description
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and syn ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296028
  • ENSP00000296028
  • ENSG00000163736

Symbol
  • CTAP3
  • CXCL7
  • SCYB7
  • TGB1
  • THBGB1
  • PBP
  • TC1
  • TC2
  • TGB
  • LDGF
  • MDGF
  • TGB1
  • B-TG1
  • CTAP3
  • CXCL7
  • NAP-2
  • SCYB7
  • THBGB
  • LA-PF4
  • THBGB1
  • Beta-TG
  • CTAPIII
  • CTAP-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
biological process
0.69
disease
0.68
gene perturbation
0.67
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2060.26   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 594   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2060.26   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
1.4
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (207)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (393)
1 – 10 of 393
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.988
Data Source: STRINGDB
PF4
Tbio
Novelty: 0.00038481
Score: 0.98
Data Source: STRINGDB
CXCR1
Tchem
Family: GPCR
Novelty: 0.00224501
Score: 0.98
Data Source: STRINGDB
CXCL11
Tbio
Novelty: 0.00077765
Score: 0.979
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.976
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.973
Data Source: STRINGDB
VWF
Tbio
Novelty: 0.00009007
Score: 0.966
Data Source: STRINGDB
CXCL6
Tbio
Novelty: 0.01019922
Score: 0.964
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.963
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  2060.26

PubMed score by year
PubTator Score  1249.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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