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Tbio
TGFA
Protransforming growth factor alpha

Protein Summary
Description
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295400
  • ENSP00000295400
  • ENSG00000163235
  • ENST00000418333
  • ENSP00000404099
  • ENST00000445399
  • ENSP00000387493

Symbol
  • TFGA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
biological term
0.92
chemical
0.84
biological process
0.82
disease
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.3   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 1290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.3   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 1290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
3
3
0
1.1
88.9
heel bone mineral density
2
2
2
83.6
1
1
0
1.1
79.9
grip strength measurement
2
2
2
77.7
osteoarthritis, hip, osteoarthritis, knee
1
1
0
1.1
73.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
0
1.1
88.9
heel bone mineral density
2
83.6
0
1.1
79.9
grip strength measurement
2
77.7
osteoarthritis, hip, osteoarthritis, knee
0
1.1
73.6
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (84)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 48
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Protein-Protein Interactions (211)
1 – 10 of 211
RAB5B
Tbio
Family: Enzyme
Novelty: 0.02653775
p_int: 0.999997016
p_ni: 0.000002983
Data Source: BioPlex
GPD2
Tbio
Family: Enzyme
Novelty: 0.00951917
p_int: 0.999479008
p_ni: 0.00052099
p_wrong: 3e-9
Data Source: BioPlex
PKMYT1
Tchem
Family: Kinase
Novelty: 0.03025516
p_int: 0.999401604
p_ni: 0.000091055
p_wrong: 0.000507341
Data Source: BioPlex
DCUN1D5
Tdark
Novelty: 0.56719852
p_int: 0.999338126
p_ni: 0.000602494
p_wrong: 0.00005938
Data Source: BioPlex
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
p_int: 0.999085734
p_ni: 0.000912196
p_wrong: 0.00000207
Data Source: BioPlex
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
p_int: 0.999042348
p_ni: 0.000668705
p_wrong: 0.000288947
Data Source: BioPlex
MOSPD2
Tbio
Novelty: 0.14602473
p_int: 0.998629952
p_ni: 0.001370048
Data Source: BioPlex
DHRS3
Tbio
Family: Enzyme
Novelty: 0.04448013
p_int: 0.998013802
p_ni: 0.001574494
p_wrong: 0.000411704
Data Source: BioPlex
PI4K2A
Tbio
Family: Kinase
Novelty: 0.03506675
p_int: 0.997817039
p_ni: 0.002182949
p_wrong: 1.2e-8
Data Source: BioPlex
PWP2
Tbio
Novelty: 0.04910741
p_int: 0.997246647
p_ni: 0.002753353
Data Source: BioPlex
Publication Statistics
PubMed Score  291.30

PubMed score by year
PubTator Score  1086.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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