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Tbio
BBS5
Bardet-Biedl syndrome 5 protein

Protein Summary
Description
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly. This gene encodes a protein that has been dir ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295240
  • ENSP00000295240
  • ENSG00000163093
  • ENST00000392663
  • ENSP00000376431
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cellular component
0.71
gene perturbation
0.62
phenotype
0.58
transcription factor binding site profile
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.35   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.35   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Protein-Protein Interactions (95)
1 – 10 of 95
BBS7
Tbio
Novelty: 0.03611111
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
BBS1
Tbio
Novelty: 0.00939439
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
BBS4
Tbio
Novelty: 0.01825873
p_int: 0.999999955
p_ni: 4.5e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
BBS9
Tbio
Novelty: 0.01879869
p_int: 0.99999985
p_ni: 1.5e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
TTC8
Tbio
Novelty: 0.08520636
p_int: 0.999999463
p_ni: 5.17e-7
p_wrong: 2e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
LZTFL1
Tbio
Novelty: 0.10578428
p_int: 0.999998538
p_ni: 0.000001462
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
NME3
Tbio
Family: Kinase
Novelty: 0.05947052
p_int: 0.999989837
p_ni: 0.000010143
p_wrong: 1.9e-8
Score: 0.857
Data Source: BioPlex,STRINGDB
BBS2
Tbio
Novelty: 0.00835161
p_int: 0.9999516
p_ni: 0.0000484
Score: 0.998
Data Source: BioPlex,STRINGDB
BBS10
Tbio
Novelty: 0.03343798
Score: 0.991
Data Source: STRINGDB
BBS12
Tbio
Novelty: 0.06131428
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.35

PubMed score by year
PubTator Score  13.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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