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Tchem
KCNJ3
G protein-activated inward rectifier potassium channel 1

Protein Summary
Description
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295101
  • ENSP00000295101
  • ENSG00000162989
  • ENST00000544049
  • ENSP00000438410

Symbol
  • GIRK1
  • KGA
  • GIRK1
  • KIR3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
disease perturbation
0.68
PubMedID
0.66
disease
0.63
microRNA
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.67   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 407   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.67   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
93.4
smoking initiation
2
2
2
68.2
intelligence
1
4
0
6
56.3
risk-taking behaviour
2
2
2
28.3
dentures
2
1
2
27.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
93.4
smoking initiation
2
68.2
intelligence
0
6
56.3
risk-taking behaviour
2
28.3
dentures
2
27.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 3
VGNC:8360
737029
Macaque
potassium voltage-gated channel subfamily J member 3
696473
Mouse
MGI:104742
16519
Rat
RGD:2958
50599
Dog
potassium voltage-gated channel subfamily J member 3
VGNC:42264
488355
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 3
Macaque
potassium voltage-gated channel subfamily J member 3
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48549-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (27)
Activation of G protein gated Potassium channels (R-HSA-1296041)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
G protein gated Potassium channels
Reactome
GABA B receptor activation
Reactome
GABA receptor activation
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
G protein gated Potassium channels
GABA B receptor activation
GABA receptor activation
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred by Curator (IC)
BHF-UCL
Inferred by Curator (IC)
BHF-UCL
Protein-Protein Interactions (117)
1 – 10 of 117
KCNJ5
Tchem
Family: IC
Novelty: 0.00385775
p_int: 0.999983481
p_wrong: 0.000016519
Score: 0.876
Data Source: BioPlex,Reactome,STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.978
Data Source: Reactome,STRINGDB
KCNJ6
Tchem
Family: IC
Novelty: 0.00330353
Score: 0.965
Data Source: Reactome,STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.953
Data Source: Reactome,STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.953
Data Source: STRINGDB
GABBR2
Tclin
Family: GPCR
Novelty: 0.00739771
Score: 0.949
Data Source: Reactome,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
Score: 0.933
Data Source: Reactome,STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.933
Data Source: Reactome,STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.916
Data Source: STRINGDB
GNG5
Tbio
Novelty: 0.1525101
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  261.67

PubMed score by year
PubTator Score  123.21

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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