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Tchem
KCNT2
Potassium channel subfamily T member 2

Protein Summary
Description
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294725
  • ENSP00000294725
  • ENSG00000162687
  • ENST00000367433
  • ENSP00000356403
  • ENST00000609185
  • ENSP00000476657

Symbol
  • SLICK
  • SLICK
  • EIEE57
  • KCa4.2
  • SLO2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
gene perturbation
0.74
histone modification site profile
0.72
phenotype
0.68
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.73   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.73   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
0
2.9
89.7
1
2
0
2.9
89.7
atrophic macular degeneration
1
2
0
2.9
89.7
chronotype measurement
1
1
1
45.3
complement C3 measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.9
89.7
0
2.9
89.7
atrophic macular degeneration
0
2.9
89.7
chronotype measurement
1
45.3
complement C3 measurement
1
13.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium sodium-activated channel subfamily T member 2
VGNC:8059
457600
Macaque
potassium sodium-activated channel subfamily T member 2
711399
Mouse
MGI:3036273
240776
Rat
RGD:735074
304827
Horse
potassium sodium-activated channel subfamily T member 2
VGNC:19313
100051286
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium sodium-activated channel subfamily T member 2
Macaque
potassium sodium-activated channel subfamily T member 2
Mouse
Rat
Horse
potassium sodium-activated channel subfamily T member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UVM3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.99988232
p_ni: 0.00011768
Data Source: BioPlex
SLC17A2
Tdark
Family: Transporter
Novelty: 0.23941275
p_int: 0.999833261
p_ni: 0.000166739
Data Source: BioPlex
IL17RC
Tclin
Novelty: 0.01844832
p_int: 0.999609638
p_ni: 0.000390362
Data Source: BioPlex
PCDHA3
Tdark
Novelty: 0.8622898
p_int: 0.999597449
p_ni: 0.000402551
Score: 0.183
Data Source: BioPlex,STRINGDB
RXFP1
Tchem
Family: GPCR
Novelty: 0.00580827
p_int: 0.999179563
p_ni: 0.000819571
p_wrong: 8.66e-7
Data Source: BioPlex
PCDHGB2
Tdark
Novelty: 1.16587709
p_int: 0.996892645
p_ni: 0.002547951
p_wrong: 0.000559404
Data Source: BioPlex
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.996640609
p_ni: 0.002439804
p_wrong: 0.000919587
Data Source: BioPlex
PCDHB16
Tdark
Novelty: 0.67206411
p_int: 0.995894238
p_ni: 0.00402233
p_wrong: 0.000083433
Data Source: BioPlex
TNFRSF10A
Tchem
Novelty: 0.0003383
p_int: 0.995883315
p_ni: 0.004034113
p_wrong: 0.000082572
Score: 0.213
Data Source: BioPlex,STRINGDB
IL4R
Tclin
Novelty: 0.00359183
p_int: 0.986958517
p_ni: 0.01251286
p_wrong: 0.000528624
Score: 0.359
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  55.73

PubMed score by year
PubTator Score  20.78

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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