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Tbio
LHX8
LIM/homeobox protein Lhx8

Protein Summary
Description
Transcription factor involved in differentiation of certain neurons and mesenchymal cells. The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294638
  • ENSP00000294638
  • ENSG00000162624
  • ENST00000356261
  • ENSP00000348597

Symbol
  • LHX7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
biological process
0.59
protein domain
0.58
PubMedID
0.55
transcription factor
0.55


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.91   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.91   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 8
VGNC:1298
469353
Macaque
LIM homeobox 8
709153
Mouse
MGI:1096343
16875
Rat
RGD:1308749
365963
Dog
LIM homeobox 8
VGNC:42668
490209
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 8
Macaque
LIM homeobox 8
Mouse
Rat
Dog
LIM homeobox 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q68G74-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (99)
1 – 10 of 99
SSBP4
Tdark
Novelty: 0.27365687
p_int: 0.999998124
p_ni: 8.4e-8
p_wrong: 0.000001791
Score: 0.45
Data Source: BioPlex,STRINGDB
SOHLH1
Tbio
Family: TF
Novelty: 0.04218087
Score: 0.939
Data Source: STRINGDB
FIGLA
Tbio
Family: TF
Novelty: 0.02544697
Score: 0.862
Data Source: STRINGDB
NOBOX
Tbio
Family: TF
Novelty: 0.01217542
Score: 0.816
Data Source: STRINGDB
NKX2-1
Tbio
Family: TF
Novelty: 0.00077491
Score: 0.81
Data Source: STRINGDB
GBX1
Tbio
Family: TF
Novelty: 0.07063263
Score: 0.773
Data Source: STRINGDB
LDB1
Tbio
Novelty: 0.01110112
Score: 0.752
Data Source: STRINGDB
YBX2
Tbio
Family: TF
Novelty: 0.01540247
Score: 0.749
Data Source: STRINGDB
BARX1
Tbio
Family: TF
Novelty: 0.02163397
Score: 0.735
Data Source: STRINGDB
DLX1
Tbio
Family: TF
Novelty: 0.01359424
Score: 0.698
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.91

PubMed score by year
PubTator Score  20.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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