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Tbio
PDPN
Podoplanin

Protein Summary
Description
Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294489
  • ENSP00000294489
  • ENSG00000162493
  • ENST00000376057
  • ENSP00000365225
  • ENST00000376061
  • ENSP00000365229
  • ENST00000475043
  • ENSP00000426063
  • ENST00000487038
  • ENSP00000427537
  • ENST00000513143
  • ENSP00000425304
  • ENST00000617617
  • ENSP00000479591
  • ENST00000621990
  • ENSP00000478125

Symbol
  • GP36
  • T1A
  • GP36
  • GP40
  • Gp38
  • OTS8
  • T1A2
  • TI1A
  • T1A-2
  • AGGRUS
  • HT1A-1
  • PA2.26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
biological term
0.92
kinase perturbation
0.91
biological process
0.82
gene perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4047.13   (req: < 5)
Gene RIFs: 199   (req: <= 3)
Antibodies: 1133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4047.13   (req: >= 5)
Gene RIFs: 199   (req: > 3)
Antibodies: 1133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
podoplanin
716250
Mouse
MGI:103098
14726
Rat
RGD:61819
54320
Dog
podoplanin
VGNC:52226
403886
Cow
podoplanin
VGNC:50142
509732
Species
Name
OMA
EggNOG
Inparanoid
Macaque
podoplanin
Mouse
Rat
Dog
podoplanin
Cow
podoplanin
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
GPVI-mediated activation cascade (R-HSA-114604)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GPVI-mediated activation cascade
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
GPVI-mediated activation cascade
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (47)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (96)
1 – 10 of 96
KIF14
Tbio
Novelty: 0.02313641
p_int: 0.999991791
p_ni: 0.000008209
Data Source: BioPlex
SLC38A7
Tdark
Family: Transporter
Novelty: 0.24353276
p_int: 0.999950954
p_ni: 0.000003472
p_wrong: 0.000045573
Data Source: BioPlex
MBLAC2
Tdark
Family: Enzyme
Novelty: 0.47407992
p_int: 0.997977937
p_ni: 0.002022062
p_wrong: 1e-9
Data Source: BioPlex
CLEC1B
Tbio
Novelty: 0.00801736
Score: 0.993
Data Source: Reactome,STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.944
Data Source: Reactome,STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.941
Data Source: STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00294726
Score: 0.923
Data Source: STRINGDB
MPIG6B
Tbio
Novelty: 0.04808462
Score: 0.911
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.909
Data Source: STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  4047.13

PubMed score by year
PubTator Score  648.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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