You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
USP24
Ubiquitin carboxyl-terminal hydrolase 24

Protein Summary
Description
Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294383
  • ENSP00000294383
  • ENSG00000162402

Symbol
  • KIAA1057
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
protein domain
0.92
transcription factor perturbation
0.84
microRNA
0.82
interacting protein
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.94   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.94   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
3
3
5
6.3
96.7
low density lipoprotein cholesterol measurement
2
3
4
6.3
95.3
blood metabolite measurement
1
1
1
85.9
lipoprotein measurement
1
1
1
85.9
lipid measurement
1
1
0
9
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
5
6.3
96.7
low density lipoprotein cholesterol measurement
4
6.3
95.3
blood metabolite measurement
1
85.9
lipoprotein measurement
1
85.9
lipid measurement
0
9
79.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 24
VGNC:1720
456881
Macaque
ubiquitin specific peptidase 24
717178
Mouse
MGI:1919936
329908
Rat
RGD:1306799
313427
Dog
ubiquitin specific peptidase 24
VGNC:48183
479558
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 24
Macaque
ubiquitin specific peptidase 24
Mouse
Rat
Dog
ubiquitin specific peptidase 24
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Protein-Protein Interactions (58)
1 – 10 of 58
BMX
Tchem
Family: Kinase
Novelty: 0.00383533
p_int: 0.999999917
p_ni: 8.3e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
CPNE2
Tdark
Novelty: 0.24188419
p_int: 0.999999529
p_ni: 4.71e-7
Score: 0.151
Data Source: BioPlex,STRINGDB
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.999996292
p_ni: 0.000003702
p_wrong: 6e-9
Score: 0.153
Data Source: BioPlex,STRINGDB
NCS1
Tbio
Novelty: 0.0051468
p_int: 0.99996608
p_ni: 0.00003392
Score: 0.17
Data Source: BioPlex,STRINGDB
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.999820346
p_ni: 0.000179654
Data Source: BioPlex
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.999631591
p_ni: 0.000368409
Data Source: BioPlex
CHRM4
Tclin
Family: GPCR
Novelty: 0.00759817
p_int: 0.998965712
p_ni: 0.001034288
Data Source: BioPlex
RHOJ
Tbio
Family: Enzyme
Novelty: 0.01217051
p_int: 0.998389519
p_ni: 0.00161048
p_wrong: 1e-9
Score: 0.254
Data Source: BioPlex,STRINGDB
SUV39H1
Tchem
Family: Epigenetic
Novelty: 0.00417439
p_int: 0.996884894
p_ni: 0.003115104
p_wrong: 2e-9
Score: 0.32
Data Source: BioPlex,STRINGDB
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
p_int: 0.990499097
p_ni: 0.009500903
Data Source: BioPlex
Publication Statistics
PubMed Score  17.94

PubMed score by year
PubTator Score  31.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: