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Tbio
LRP5
Low-density lipoprotein receptor-related protein 5

Protein Summary
Description
Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503, PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed:11336703, PubMed:25920554, PubMed:24706814, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294304
  • ENSP00000294304
  • ENSG00000162337

Symbol
  • LR3
  • LRP7
  • HBM
  • LR3
  • OPS
  • EVR1
  • EVR4
  • LRP7
  • OPPG
  • BMND1
  • LRP-5
  • LRP-7
  • OPTA1
  • PCLD4
  • VBCH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.9
protein domain
0.85
phenotype
0.83
gene perturbation
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1076.07   (req: < 5)
Gene RIFs: 186   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1076.07   (req: >= 5)
Gene RIFs: 186   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
7
4
8
99.3
heel bone mineral density
3
8
17
98.1
testosterone measurement
2
2
2
95.8
appendicular lean mass
2
1
2
95.2
mathematical ability
4
1
4
87.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
8
99.3
heel bone mineral density
17
98.1
testosterone measurement
2
95.8
appendicular lean mass
2
95.2
mathematical ability
4
87.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 5
VGNC:3109
451380
Mouse
MGI:1278315
16973
Rat
RGD:1309329
293649
Dog
LDL receptor related protein 5
VGNC:49918
100306933
Pig
LDL receptor related protein 5
100524299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 5
Mouse
Rat
Dog
LDL receptor related protein 5
Pig
LDL receptor related protein 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75197-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (157)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (R-HSA-4641262)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Name
Explore in Pharos
Explore in Source
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disease
Diseases of signal transduction
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Gene Ontology Terms (37)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Protein-Protein Interactions (229)
1 – 10 of 229
POMK
Tbio
Family: Kinase
Novelty: 0.09340344
p_int: 0.999967392
p_ni: 0.000032608
Data Source: BioPlex
ETV6
Tbio
Family: TF
Novelty: 0.00151718
p_int: 0.999782458
p_ni: 0.000217542
Score: 0.312
Data Source: BioPlex,STRINGDB
SOST
Tclin
Novelty: 0.0009273
p_int: 0.999754372
p_ni: 0.000245628
Score: 0.995
Data Source: BioPlex,STRINGDB
PARP16
Tbio
Family: Enzyme
Novelty: 0.09651799
p_int: 0.999731507
p_ni: 0.000268493
Data Source: BioPlex
GPATCH2
Tdark
Novelty: 0.03284393
p_int: 0.999702904
p_ni: 0.000297096
Data Source: BioPlex
PRSS37
Tdark
Family: Enzyme
Novelty: 0.40482351
p_int: 0.998650834
p_ni: 0.001349166
Data Source: BioPlex
CSNK1A1
Tchem
Family: Kinase
Novelty: 0.00636472
p_int: 0.998516524
p_ni: 0.001483476
Score: 0.946
Data Source: BioPlex,STRINGDB
TGIF2LY
Tdark
Family: TF
p_int: 0.998096806
p_ni: 0.001903194
Data Source: BioPlex
RNF10
Tbio
Novelty: 0.09086567
p_int: 0.991943237
p_ni: 0.008051045
p_wrong: 0.000005718
Data Source: BioPlex
DKKL1
Tbio
Novelty: 0.00544618
p_int: 0.989486402
p_ni: 0.010513597
p_wrong: 1e-9
Score: 0.531
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1076.07

PubMed score by year
PubTator Score  542.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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