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Tclin
SSTR5
Somatostatin receptor type 5

Protein Summary
Description
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293897
  • ENSP00000293897
  • ENSG00000162009

Symbol
  • SS-5-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.97
co-expressed gene
0.93
biological process
0.67
protein domain
0.58
molecular function
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.97   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.97   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 270
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
83.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
83.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:894282
20609
Rat
RGD:3765
25354
Dog
somatostatin receptor 5
VGNC:46846
403454
Horse
somatostatin receptor 5
VGNC:23623
100067398
Cow
somatostatin receptor 5
VGNC:35328
510344
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
somatostatin receptor 5
Horse
somatostatin receptor 5
Cow
somatostatin receptor 5
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (278)
1 – 10 of 278
SST
Tbio
Novelty: 0.00005944
Score: 0.995
Data Source: STRINGDB
CORT
Tbio
Novelty: 0.00789975
Score: 0.973
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.962
Data Source: STRINGDB
GRM8
Tchem
Family: GPCR
Novelty: 0.00827879
Score: 0.957
Data Source: STRINGDB
DRD2
Tclin
Family: GPCR
Novelty: 0.00033797
Score: 0.95
Data Source: STRINGDB
RLN3
Tbio
Novelty: 0.0107593
Score: 0.946
Data Source: STRINGDB
SSTR1
Tclin
Family: GPCR
Novelty: 0.00588024
Score: 0.94
Data Source: STRINGDB
PPY
Tbio
Novelty: 0.00060933
Score: 0.94
Data Source: STRINGDB
TAS2R4
Tbio
Family: GPCR
Novelty: 0.02938385
Score: 0.936
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  159.97

PubMed score by year
PubTator Score  247.52

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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