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Tbio
CCDC78
Coiled-coil domain-containing protein 78

Protein Summary
Description
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome. The product of this gene contains two coiled-coil domains. The function of this gene is currently unknown. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293889
  • ENSP00000293889
  • ENSG00000162004

Symbol
  • C16orf25
  • CNM4
  • JFP10
  • C16orf25
  • hsCCDC78
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.67
transcription factor
0.61
tissue sample
0.49
histone modification site profile
0.48
cell line
0.46


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.17   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.17   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 78
722379
Mouse
MGI:2685784
381077
Dog
coiled-coil domain containing 78
VGNC:38856
490088
Cow
coiled-coil domain containing 78
VGNC:26916
511835
Opossum
coiled-coil domain containing 78
100619976
Species
Name
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 78
Mouse
Dog
coiled-coil domain containing 78
Cow
coiled-coil domain containing 78
Opossum
coiled-coil domain containing 78
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A2IDD5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (36)
1 – 10 of 36
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.998451673
p_ni: 0.001546252
p_wrong: 0.000002076
Data Source: BioPlex
CORO1A
Tbio
Novelty: 0.00898925
p_int: 0.969598129
p_ni: 0.030397742
p_wrong: 0.000004129
Data Source: BioPlex
ZNF516
Tbio
Family: TF
Novelty: 0.22650006
Score: 0.816
Data Source: STRINGDB
MCIDAS
Tbio
Novelty: 0.01249062
Score: 0.757
Data Source: STRINGDB
CTBP2
Tchem
Novelty: 0.00538964
Score: 0.719
Data Source: STRINGDB
DEUP1
Tbio
Novelty: 0.13274391
Score: 0.683
Data Source: STRINGDB
BBOF1
Tdark
Novelty: 0.82370886
Score: 0.657
Data Source: STRINGDB
LRPAP1
Tbio
Novelty: 0.00214194
Score: 0.638
Data Source: STRINGDB
CEP152
Tbio
Novelty: 0.02129779
Score: 0.584
Data Source: STRINGDB
SASS6
Tbio
Novelty: 0.00680548
Score: 0.553
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.17

PubMed score by year
PubTator Score  1.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer