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Tchem
CELA1
Chymotrypsin-like elastase family member 1

Protein Summary
Description
Acts upon elastin. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293636
  • ENSP00000293636
  • ENSG00000139610

Symbol
  • ELA1
  • ELA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.77
gene perturbation
0.67
biological process
0.62
disease perturbation
0.62
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.08   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.08   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
telaprevir
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
1
1
1
78
neutrophil count
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
1
78
neutrophil count
1
8.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chymotrypsin like elastase family member 1
VGNC:5333
740437
Macaque
chymotrypsin like elastase family member 1
695507
Mouse
MGI:95314
109901
Rat
RGD:2547
24331
Dog
chymotrypsin like elastase family member 1
VGNC:39092
403515
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chymotrypsin like elastase family member 1
Macaque
chymotrypsin like elastase family member 1
Mouse
Rat
Dog
chymotrypsin like elastase family member 1
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (48)
1 – 10 of 48
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.999928545
p_ni: 0.000071455
Data Source: BioPlex
SMYD2
Tchem
Family: Epigenetic
Novelty: 0.0192516
p_int: 0.99642101
p_ni: 0.003468042
p_wrong: 0.000110948
Score: 0.187
Data Source: BioPlex,STRINGDB
PRR14
Tbio
Novelty: 0.22401806
p_int: 0.994863935
p_ni: 0.000164831
p_wrong: 0.004971235
Data Source: BioPlex
SIPA1L2
Tbio
Novelty: 0.2002618
p_int: 0.994659166
p_ni: 0.005287385
p_wrong: 0.000053449
Score: 0.173
Data Source: BioPlex,STRINGDB
GLI3
Tbio
Family: TF
Novelty: 0.00051217
p_int: 0.990796747
p_ni: 0.007986881
p_wrong: 0.001216372
Score: 0.235
Data Source: BioPlex,STRINGDB
ZNF318
Tbio
Novelty: 0.03072403
p_int: 0.98596218
p_ni: 0.014037815
p_wrong: 5e-9
Data Source: BioPlex
KRBA1
Tdark
Novelty: 2.59384945
p_int: 0.962979507
p_ni: 0.037018164
p_wrong: 0.00000233
Data Source: BioPlex
BCOR
Tbio
Novelty: 0.05718292
p_int: 0.959490495
p_ni: 0.040509505
Data Source: BioPlex
HDAC3
Tclin
Family: Epigenetic
Novelty: 0.00393172
p_int: 0.944434767
p_ni: 0.055550934
p_wrong: 0.000014299
Score: 0.169
Data Source: BioPlex,STRINGDB
CEP164
Tbio
Novelty: 0.04775724
p_int: 0.941351412
p_ni: 0.05832997
p_wrong: 0.000318618
Score: 0.181
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  335.08

PubMed score by year
PubTator Score  251.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer