You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
KLHL10
Kelch-like protein 10

Protein Summary
Description
May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293303
  • ENSP00000293303
  • ENSG00000161594

Symbol
  • SPGF11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.86
cell type or tissue
0.66
tissue sample
0.62
tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
1
3
60.5
reticulocyte measurement
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
60.5
reticulocyte measurement
1
26.3
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (68)
1 – 10 of 68
RAD51C
Tbio
Novelty: 0.0063568
p_int: 0.999996895
p_ni: 0.000003105
Score: 0.167
Data Source: BioPlex,STRINGDB
FBXL17
Tbio
Novelty: 0.16122137
p_int: 0.998860844
p_ni: 0.000104843
p_wrong: 0.001034314
Score: 0.158
Data Source: BioPlex,STRINGDB
COPS7A
Tbio
Novelty: 0.02159233
p_int: 0.997534008
p_ni: 0.00246599
p_wrong: 2e-9
Score: 0.6
Data Source: BioPlex,STRINGDB
COPS2
Tbio
Novelty: 0.03509351
p_int: 0.997170199
p_ni: 0.002829796
p_wrong: 4e-9
Score: 0.663
Data Source: BioPlex,STRINGDB
COPS7B
Tbio
Novelty: 0.63421506
p_int: 0.9948868
p_ni: 0.005113199
p_wrong: 1e-9
Score: 0.531
Data Source: BioPlex,STRINGDB
MVK
Tchem
Family: Kinase
Novelty: 0.00328607
p_int: 0.993184886
p_ni: 0.006815114
p_wrong: 1e-9
Score: 0.191
Data Source: BioPlex,STRINGDB
PRMT3
Tchem
Family: Epigenetic
Novelty: 0.03433797
p_int: 0.992658353
p_ni: 0.007341609
p_wrong: 3.8e-8
Score: 0.215
Data Source: BioPlex,STRINGDB
COPS5
Tbio
Novelty: 0.00406225
p_int: 0.988462269
p_ni: 0.011537731
Score: 0.577
Data Source: BioPlex,STRINGDB
COPS6
Tbio
Novelty: 0.02653008
p_int: 0.986684482
p_ni: 0.013315518
Score: 0.663
Data Source: BioPlex,STRINGDB
DNAJB5
Tbio
Novelty: 0.20703358
p_int: 0.980041531
p_ni: 0.019955313
p_wrong: 0.000003157
Data Source: BioPlex
Publication Statistics
PubMed Score  10.19

PubMed score by year
PubTator Score  4.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: