Tchem BAX Apoptosis regulator BAX

Protein Summary

Description

Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07812
• A8K4W1
• P55269
• Q07814
• Q07815
• Q8WZ49
• Q9NR76
• Q9NYG7
• Q9UCZ6
• Q9UCZ7
• Q9UQD6

Gene Name

• BAX

Ensembl ID

• ENST00000293288
• ENSP00000293288
• ENSG00000087088
• ENST00000345358
• ENSP00000263262
• ENST00000354470
• ENSP00000346461
• ENST00000356483
• ENSP00000348871
• ENST00000415969
• ENSP00000389971
• ENST00000515540
• ENSP00000426328

Symbol

• BCL2L4
• BCL2L4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
disease perturbation	0.99
cellular component	0.92
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Apoptosis Regulator Bax

DTO Classes

Protein / Signaling / Apoptosis Regulator Bax

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.61   (req: < 5)

Gene RIFs: 746   (req: <= 3)

Antibodies: 1862   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.61   (req: >= 5)

Gene RIFs: 746   (req: > 3)

Antibodies: 1862   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 96

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (3)

Explore Active Ligands

1 – 3 of 3

CHEMBL4579601

BAXTchem

pIC50 : 7.37

CHEMBL3417402

BAXTchem

pKi : 6.1

CHEMBL3417409

BAXTchem

pKi : 6

Protein-Protein Interactions (131)

Explore Interacting Targets

1 – 10 of 131

• See Interactions on String-DB

BCL2L2

Tchem

Novelty:  0.00430896

p_int:  0.999995545

p_ni:  0.000004455

Score:  0.749

Data Source:  BioPlex,STRINGDB

BCL2

Tclin

Novelty:  0.00608635

p_int:  0.999881038

p_ni:  0.000118962

Score:  0.967

Data Source:  BioPlex,STRINGDB

MCL1

Tchem

Novelty:  0.00046181

p_int:  0.999471446

p_ni:  0.000528554

Score:  0.996

Data Source:  BioPlex,STRINGDB

BCL2L15

Tbio

Novelty:  0.11260258

p_int:  0.999350647

p_ni:  0.000649353

Score:  0.365

Data Source:  BioPlex,STRINGDB

C6orf222

Tdark

Novelty:  37

p_int:  0.997676932

p_ni:  0.002323068

Data Source:  BioPlex

BCL2L10

Tchem

Novelty:  0.01389535

p_int:  0.997268349

p_ni:  0.002731651

Score:  0.473

Data Source:  BioPlex,STRINGDB

BCL2L1

Tchem

Novelty:  0.00018414

p_int:  0.996556649

p_ni:  0.003443351

Score:  0.998

Data Source:  BioPlex,STRINGDB

BCL2L12

Tbio

Novelty:  0.01773637

p_int:  0.995879491

p_ni:  0.004120509

Score:  0.579

Data Source:  BioPlex,STRINGDB

BCL2L11

Tchem

Novelty:  0.00055914

Score:  0.995

Data Source:  STRINGDB

BID

Tbio

Novelty:  0.01264688

Score:  0.993

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets (3)

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Upstream (2)

Downstream (1)

1 – 2 of 2

BCL2

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  22

1: Platinum drug resistance

2: EGFR tyrosine kinase inhibitor resistance

3: Endocrine resistance

4: Gastric cancer

more:  18 more common pathways

CSF2RB

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  2

1: Pathways in cancer

2: Apoptosis

Pathways (117)

Reactome (20)

KEGG (44)

PathwayCommons (18)

WikiPathways (35)

Activation, translocation and oligomerization of BAX (R-HSA-114294)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation, translocation and oligomerization of BAX	2 targets	R-HSA-114294
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Apoptotic factor-mediated response	16 targets	R-HSA-111471
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Activation, translocation and oligomerization of BAX	2 targets	R-HSA-114294
Apoptosis	177 targets	R-HSA-109581
Apoptotic factor-mediated response	16 targets	R-HSA-111471
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (110)

Functions (8)

Components (14)

Processes (88)

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1 – 8 of 8

GO Term	Evidence	Assigned by
BH3 domain binding	Inferred from Direct Assay (IDA)	UniProtKB
channel activity	Inferred from Direct Assay (IDA)	BHF-UCL
lipid binding	Inferred from Direct Assay (IDA)	HGNC
protein homodimerization activity	Inferred from Direct Assay (IDA)	HGNC
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	HGNC
chaperone binding	Inferred from Electronic Annotation (IEA)	Ensembl
Hsp70 protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (14)

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1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3	5	6		96.1
red blood cell distribution width	EFO_0005192	4	3	5		95.1
reticulocyte count	EFO_0007986	6	4	12		94.4
testosterone measurement	EFO_0004908	6	6	6		88
eosinophil count	EFO_0004842	3	1	3		70.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	6		96.1
red blood cell distribution width	EFO_0005192	5		95.1
reticulocyte count	EFO_0007986	12		94.4
testosterone measurement	EFO_0004908	6		88
eosinophil count	EFO_0004842	3		70.9

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Apoptosis
Complete proteome
Cytoplasm
Host-virus interaction
Membrane
Mitochondrion
Mitochondrion outer membrane

GWAS Trait Find Similar Targets

No Header	No Header
eosinophil count
eosinophil percentage of leukocytes
ferritin measurement
heel bone mineral density
leukocyte count
lymphocyte count
mean corpuscular hemoglobin concentration
neutrophil percentage of granulocytes
platelet crit
red blood cell distribution width

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype
renal/urinary system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	BCL2 associated X, apoptosis regulator	VGNC:10275	747093
Macaque	BCL2 associated X, apoptosis regulator		718948
Mouse	BCL2-associated X protein	MGI:99702	12028
Rat	BCL2 associated X, apoptosis regulator	RGD:2192	24887
Dog	BCL2 associated X, apoptosis regulator	VGNC:38388	403523

Species	Name	OMA	EggNOG	Inparanoid
Chimp	BCL2 associated X, apoptosis regulator
Macaque	BCL2 associated X, apoptosis regulator
Mouse	BCL2-associated X protein
Rat	BCL2 associated X, apoptosis regulator
Dog	BCL2 associated X, apoptosis regulator

Publication Statistics

PubMed Score 424.61

PubMed score by year

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PubTator Score 6579.14

PubTator score by year

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Related Publications

Text Mined References (885)

GeneRif Annotations (746)

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PMID	Year	Title