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Tclin
FGFR4
Fibroblast growth factor receptor 4

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292408
  • ENSP00000292408
  • ENSG00000160867
  • ENST00000393637
  • ENSP00000377254
  • ENST00000502906
  • ENSP00000424960

Symbol
  • JTK2
  • TKF
  • TKF
  • JTK2
  • CD334
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
biological process
0.95
PubMedID
0.9
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 384.81   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 736   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 384.81   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 736   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 461
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
nintedanib
chemical structure image
erdafitinib
chemical structure image
Active Ligands (461)
1 – 10 of 461
CHEMBL3984039,CHEMBL3962736
chemical structure image
CHEMBL3907195,CHEMBL3944340
chemical structure image
CHEMBL3931421,CHEMBL3955800
chemical structure image
CHEMBL3927451,CHEMBL3902353
chemical structure image
CHEMBL3919730,CHEMBL3967645
chemical structure image
CHEMBL3909529,CHEMBL3934260
chemical structure image
CHEMBL3897101,CHEMBL3935825
chemical structure image
CHEMBL3932577,CHEMBL3935264
chemical structure image
CHEMBL3959345,CHEMBL3925286
chemical structure image
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
3
10
98.6
hip geometry
1
1
1
86.9
body height
3
2
3
85.7
body fat distribution
1
1
1
51.8
low density lipoprotein cholesterol measurement
1
1
1
48.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
98.6
hip geometry
1
86.9
body height
3
85.7
body fat distribution
1
51.8
low density lipoprotein cholesterol measurement
1
48.1
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (110)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signaling of activated FGFR4
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signaling of activated FGFR4
Gene Ontology Terms (41)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (173)
1 – 10 of 173
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.999998184
p_ni: 0.000001816
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.999983486
p_ni: 0.000016508
p_wrong: 6e-9
Score: 0.16
Data Source: BioPlex,STRINGDB
TMX1
Tbio
Novelty: 0.03444237
p_int: 0.999979789
p_ni: 0.000020033
p_wrong: 1.78e-7
Score: 0.223
Data Source: BioPlex,STRINGDB
LRRIQ1
Tdark
Novelty: 1.8251367
p_int: 0.999976021
p_ni: 0.000017851
p_wrong: 0.000006128
Score: 0.183
Data Source: BioPlex,STRINGDB
MRAP2
Tbio
Novelty: 0.0420503
p_int: 0.99996634
p_ni: 0.000028737
p_wrong: 0.000004924
Data Source: BioPlex
TNFRSF10A
Tchem
Novelty: 0.0003383
p_int: 0.999959782
p_ni: 0.000035298
p_wrong: 0.00000492
Data Source: BioPlex
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.999937085
p_ni: 0.00006291
p_wrong: 5e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
SLC39A5
Tbio
Family: Transporter
Novelty: 0.05205571
p_int: 0.991399246
p_ni: 0.001688936
p_wrong: 0.006911818
Score: 0.196
Data Source: BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty: 0.01594053
p_int: 0.985179999
p_ni: 0.010930346
p_wrong: 0.003889655
Data Source: BioPlex
FGF1
Tchem
Novelty: 0.00055979
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  384.81

PubMed score by year
PubTator Score  285.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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