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Tbio
S100A1
Protein S100-A1

Protein Summary
Description
Probably acts as a Ca(2+) signal transducer (PubMed:22399290). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (PubMed:22399290). The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been impl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292169
  • ENSP00000292169
  • ENSG00000160678

Symbol
  • S100A
  • S100
  • S100A
  • S100-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.8
biological term
0.71
gene perturbation
0.71
tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.25   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 1056   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.25   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 1056   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of TLR by endogenous ligand
Reactome
Toll-like Receptor Cascades
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Regulation of TLR by endogenous ligand
Toll-like Receptor Cascades
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (69)
1 – 10 of 69
TLR4
Tchem
Novelty: 0.00013074
Score: 0.955
Data Source: Reactome,STRINGDB
PPID
Tchem
Family: Enzyme
Novelty: 0.01487032
Score: 0.944
Data Source: STRINGDB
FKBP4
Tchem
Family: Enzyme
Novelty: 0.00175302
Score: 0.932
Data Source: STRINGDB
LY96
Tchem
Novelty: 0.00114737
Score: 0.921
Data Source: Reactome,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00020424
Score: 0.897
Data Source: STRINGDB
S100A4
Tbio
Novelty: 0.00156469
Score: 0.841
Data Source: STRINGDB
S100B
Tchem
Novelty: 0.00038202
Score: 0.832
Data Source: STRINGDB
HSP90AB1
Tchem
Novelty: 0.01466977
Score: 0.826
Data Source: STRINGDB
S100Z
Tbio
Novelty: 0.18651431
Score: 0.816
Data Source: STRINGDB
S100A2
Tbio
Novelty: 0.01191452
Score: 0.794
Data Source: STRINGDB
Publication Statistics
PubMed Score  310.25

PubMed score by year
PubTator Score  3878.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer