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Tbio
SIGLEC12
Sialic acid-binding Ig-like lectin 12

Protein Classes
Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291707
  • ENSP00000291707
  • ENSG00000254521
  • ENST00000598614
  • ENSP00000472873

Symbol
  • SIGLECL1
  • SLG
  • S2V
  • SLG
  • SIGLECL1
  • Siglec-XII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell line
0.71
cell type or tissue
0.58
tissue
0.37
biological term
0.34


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (17)
1 – 10 of 17
MIA3
Tbio
Novelty: 0.02784348
p_int: 0.999997035
p_ni: 0.000002942
p_wrong: 2.3e-8
Score: 0.237
Data Source: BioPlex,STRINGDB
TEX261
Tdark
Novelty: 0.66416503
p_int: 0.982191705
p_wrong: 0.017808295
Score: 0.54
Data Source: BioPlex,STRINGDB
PLAA
Tchem
Family: Enzyme
Novelty: 0.01164687
p_int: 0.975476714
p_ni: 0.024523286
Score: 0.256
Data Source: BioPlex,STRINGDB
SLC39A11
Tbio
Family: Transporter
Novelty: 0.09770302
p_int: 0.97170951
p_ni: 0.02829049
Score: 0.183
Data Source: BioPlex,STRINGDB
TUBGCP3
Tbio
Novelty: 0.0221126
p_int: 0.873261097
p_ni: 0.126738898
p_wrong: 5e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.86805314
p_ni: 0.13194686
Data Source: BioPlex
UFSP2
Tbio
Family: Enzyme
Novelty: 0.12630722
p_int: 0.830196229
p_ni: 0.169803771
Score: 0.179
Data Source: BioPlex,STRINGDB
MTX1
Tbio
Novelty: 0.02350764
p_int: 0.822283504
p_ni: 0.177716462
p_wrong: 3.4e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
HAGH
Tbio
Family: Enzyme
Novelty: 0.00689153
Score: 0.675
Data Source: STRINGDB
SLC6A4
Tclin
Family: Transporter
Novelty: 0.00017603
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.37

PubMed score by year
PubTator Score  57.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer