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Tbio
CRYAA
Alpha-crystallin A chain

Protein Summary
Description
Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291554
  • ENSP00000291554
  • ENSG00000160202

Symbol
  • CRYA1
  • HSPB4
  • CRT1
  • CRTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.72
biological term
0.64
cellular component
0.54
hub protein
0.53
cell type or tissue
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.39   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.39   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
41.6
Alopecia
1
2
2
27.5
Age-related nuclear cataract
1
1
1
6.4
diastolic blood pressure
1
1
1
6.2
Agents acting on the renin-angiotensin system use measurement
1
1
1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
41.6
Alopecia
2
27.5
Age-related nuclear cataract
1
6.4
diastolic blood pressure
1
6.2
Agents acting on the renin-angiotensin system use measurement
1
0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha-crystallin A chain
458589
Macaque
crystallin alpha A
722370
Mouse
MGI:88515
12954
Rat
RGD:2413
24273
Dog
crystallin alpha A
487786
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha-crystallin A chain
Macaque
crystallin alpha A
Mouse
Rat
Dog
crystallin alpha A
Protein-Protein Interactions (114)
1 – 10 of 114
NYNRIN
Tdark
Novelty: 0.12231563
p_int: 0.99999982
p_ni: 4.9e-8
p_wrong: 1.31e-7
Data Source: BioPlex
ATF7IP
Tbio
Novelty: 0.04269323
p_int: 0.999991771
p_ni: 0.000008228
p_wrong: 1e-9
Data Source: BioPlex
TRIM33
Tbio
Family: Epigenetic
Novelty: 0.00415877
p_int: 0.99998547
p_ni: 0.000014531
Data Source: BioPlex
GSE1
Tdark
Novelty: 0.04331197
p_int: 0.999982749
p_ni: 0.00001725
p_wrong: 1e-9
Data Source: BioPlex
ZNF318
Tbio
Novelty: 0.03072403
p_int: 0.999979959
p_ni: 0.000020041
Data Source: BioPlex
ZMYM2
Tbio
Novelty: 0.0258698
p_int: 0.999946436
p_ni: 0.000053564
Data Source: BioPlex
ZDHHC16
Tbio
Family: Enzyme
Novelty: 0.25774744
p_int: 0.999913753
p_ni: 7.11e-7
p_wrong: 0.000085536
Data Source: BioPlex
SMG7
Tbio
Novelty: 0.03394393
p_int: 0.999900914
p_ni: 0.000099035
p_wrong: 5.1e-8
Data Source: BioPlex
SATB2
Tbio
Family: TF
Novelty: 0.00405935
p_int: 0.999853185
p_ni: 0.000146809
p_wrong: 6e-9
Data Source: BioPlex
ZMYM6
Tdark
Novelty: 0.4933879
p_int: 0.99982405
p_ni: 0.000175901
p_wrong: 5e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  116.39

PubMed score by year
PubTator Score  84.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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