You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SHF
SH2 domain-containing adapter protein F

Protein Summary
Description
Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290894
  • ENSP00000290894
  • ENSG00000138606
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
transcription factor
0.66
cellular component
0.63
cell line
0.6
histone modification site profile
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (29)
1 – 10 of 29
PDGFRA
Tclin
Family: Kinase
Novelty: 0.00066909
Score: 0.939
Data Source: STRINGDB
PPAN
Tbio
Novelty: 0.01063709
Score: 0.925
Data Source: STRINGDB
IPO5
Tbio
Novelty: 0.00452607
Score: 0.585
Data Source: STRINGDB
SH2D6
Tdark
Novelty: 0.99620493
Score: 0.545
Data Source: STRINGDB
SHISAL2A
Tdark
Novelty: 12.70588235
Score: 0.526
Data Source: STRINGDB
PGAP2
Tbio
Novelty: 0.06145169
Score: 0.522
Data Source: STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.519
Data Source: STRINGDB
POLRMT
Tbio
Family: Enzyme
Novelty: 0.01398067
Score: 0.502
Data Source: STRINGDB
SERPINF2
Tbio
Novelty: 0.00054719
Score: 0.488
Data Source: STRINGDB
ALK
Tclin
Family: Kinase
Novelty: 0.00022375
Score: 0.487
Data Source: STRINGDB
Publication Statistics
PubMed Score  50.82

PubMed score by year
PubTator Score  15.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer