You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KCNE2
Potassium voltage-gated channel subfamily E member 2

Protein Summary
Description
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290310
  • ENSP00000290310
  • ENSG00000159197

Symbol
  • LQT5
  • LQT6
  • ATFB4
  • MIRP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.77
gene perturbation
0.77
tissue sample
0.66
cellular component
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.53   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.53   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 2
VGNC:7464
746889
Mouse
MGI:1891123
246133
Rat
RGD:621383
171138
Dog
potassium voltage-gated channel subfamily E regulatory subunit 2
VGNC:42241
403471
Horse
potassium voltage-gated channel subfamily E regulatory subunit 2
VGNC:19271
100062720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 2
Mouse
Rat
Dog
potassium voltage-gated channel subfamily E regulatory subunit 2
Horse
potassium voltage-gated channel subfamily E regulatory subunit 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6J6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 2 - plateau phase
Reactome
Phase 3 - rapid repolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 2 - plateau phase
Phase 3 - rapid repolarisation
Gene Ontology Terms (33)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (83)
1 – 10 of 83
KCNH2
Tclin
Family: IC
Novelty: 0.00041611
Score: 0.995
Data Source: Reactome,STRINGDB
KCNQ1
Tclin
Family: IC
Novelty: 0.0008956
Score: 0.993
Data Source: Reactome,STRINGDB
AKAP9
Tbio
Family: Enzyme
Novelty: 0.0106532
Score: 0.967
Data Source: Reactome,STRINGDB
KCNE3
Tbio
Family: IC
Novelty: 0.01541806
Score: 0.884
Data Source: STRINGDB
SCN5A
Tclin
Family: IC
Novelty: 0.00050944
Score: 0.867
Data Source: STRINGDB
KCNE4
Tbio
Family: IC
Novelty: 0.04524673
Score: 0.842
Data Source: STRINGDB
KCNJ2
Tchem
Family: IC
Novelty: 0.00290395
Score: 0.818
Data Source: STRINGDB
CACNA1C
Tclin
Family: IC
Novelty: 0.00099998
Score: 0.797
Data Source: STRINGDB
KCNE5
Tbio
Novelty: 0.06395873
Score: 0.749
Data Source: STRINGDB
SCN4B
Tbio
Family: IC
Novelty: 0.02505113
Score: 0.737
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.53

PubMed score by year
PubTator Score  97.18

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: