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Tbio
IFNGR2
Interferon gamma receptor 2

Protein Summary
Description
Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290219
  • ENSP00000290219
  • ENSG00000159128
  • ENST00000576463
  • ENSP00000458487
  • ENSG00000262795

Symbol
  • IFNGT1
  • AF-1
  • IFGR2
  • IMD28
  • IFNGT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
transcription factor perturbation
0.91
transcription factor binding site profile
0.77
PubMedID
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.24   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 383   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.24   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
77.5
1
1
0
1.1
34.7
1
1
0
1.1
30.2
1
1
0
1.1
29.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
77.5
0
1.1
34.7
0
1.1
30.2
0
1.1
29.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon gamma receptor 2
VGNC:14663
470077
Macaque
interferon gamma receptor 2
699489
Mouse
MGI:107654
15980
Rat
RGD:1307532
360697
Dog
interferon gamma receptor 2
487739
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon gamma receptor 2
Macaque
interferon gamma receptor 2
Mouse
Rat
Dog
interferon gamma receptor 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (32)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Reactome
Regulation of IFNG signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Regulation of IFNG signaling
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (102)
1 – 10 of 102
IFNGR1
Tbio
Novelty: 0.00417244
Score: 0.991
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.979
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.976
Data Source: Reactome,STRINGDB
IFNG
Tclin
Novelty: 0.00009731
Score: 0.968
Data Source: Reactome,STRINGDB
IFNAR2
Tclin
Novelty: 0.00453303
Score: 0.95
Data Source: STRINGDB
SOCS1
Tbio
Novelty: 0.00131368
Score: 0.935
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.933
Data Source: Reactome,STRINGDB
SOCS3
Tbio
Novelty: 0.00106095
Score: 0.926
Data Source: Reactome,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.912
Data Source: Reactome,STRINGDB
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
Score: 0.908
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  63.24

PubMed score by year
PubTator Score  264.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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