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Tbio
NBL1
Neuroblastoma suppressor of tumorigenicity 1

Protein Summary
Description
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289749
  • ENSP00000289749
  • ENSG00000158747
  • ENST00000375136
  • ENSP00000364278
  • ENST00000548815
  • ENSP00000449007
  • ENST00000602662
  • ENSP00000473411
  • ENST00000618761
  • ENSP00000483061
  • ENST00000621723
  • ENSP00000478885
  • ENST00000622566
  • ENSP00000480391

Symbol
  • DAN
  • DAND1
  • DAN
  • NBL1
  • DAND1
  • MINOS1-NBL1
  • C1orf151-NBL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
transcription factor
0.74
disease
0.71
cell type or tissue
0.66
small molecule perturbation
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 380.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 380.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (36)
1 – 10 of 36
PTH
Tbio
Novelty: 0.00003793
Score: 0.792
Data Source: STRINGDB
NHLRC1
Tbio
Family: Enzyme
Novelty: 0.01215525
Score: 0.76
Data Source: STRINGDB
SLPI
Tbio
Family: Enzyme
Novelty: 0.00244182
Score: 0.754
Data Source: STRINGDB
GC
Tchem
Novelty: 0.00077739
Score: 0.737
Data Source: STRINGDB
COG8
Tbio
Novelty: 0.01243501
Score: 0.731
Data Source: STRINGDB
CYP27B1
Tchem
Family: Enzyme
Novelty: 0.00188386
Score: 0.701
Data Source: STRINGDB
VDR
Tclin
Family: NR
Novelty: 0.00022662
Score: 0.7
Data Source: STRINGDB
CYP24A1
Tchem
Family: Enzyme
Novelty: 0.00108437
Score: 0.7
Data Source: STRINGDB
FGF23
Tclin
Novelty: 0.00057077
Score: 0.671
Data Source: STRINGDB
CYP2R1
Tbio
Family: Enzyme
Novelty: 0.00912049
Score: 0.655
Data Source: STRINGDB
Publication Statistics
PubMed Score  380.54

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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