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Tbio
FANCC
Fanconi anemia group C protein

Protein Summary
Description
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289081
  • ENSP00000289081
  • ENSG00000158169
  • ENST00000375305
  • ENSP00000364454

Symbol
  • FAC
  • FACC
  • FA3
  • FAC
  • FACC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
co-expressed gene
0.85
disease perturbation
0.79
histone modification site profile
0.73
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.32   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.32   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
51.9
visual cortical surface area measurement
1
2
2
25.2
neuroticism measurement
1
1
0
5.7
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
51.9
visual cortical surface area measurement
2
25.2
neuroticism measurement
0
5.7
11.2
Pathways (10)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (119)
1 – 10 of 119
CENPS
Tbio
Novelty: 0.0085893
Score: 0.999
Data Source: STRINGDB
FANCG
Tbio
Novelty: 0.00908902
Score: 0.999
Data Source: STRINGDB
FANCM
Tbio
Novelty: 0.01122278
Score: 0.999
Data Source: STRINGDB
FANCE
Tbio
Novelty: 0.04484113
Score: 0.999
Data Source: STRINGDB
CENPX
Tbio
Novelty: 0.08344454
Score: 0.999
Data Source: STRINGDB
FAAP100
Tdark
Novelty: 0.1698504
Score: 0.999
Data Source: STRINGDB
FANCF
Tchem
Novelty: 0.01745498
Score: 0.999
Data Source: STRINGDB
FANCA
Tbio
Novelty: 0.00324947
Score: 0.999
Data Source: STRINGDB
FANCL
Tbio
Family: Enzyme
Novelty: 0.00274467
Score: 0.999
Data Source: STRINGDB
HES1
Tbio
Family: TF
Novelty: 0.00974115
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  190.32

PubMed score by year
PubTator Score  618.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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