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Tbio
GRHL3
Grainyhead-like protein 3 homolog

Protein Classes
Protein Summary
Description
Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establis ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236255
  • ENSP00000236255
  • ENSG00000158055
  • ENST00000350501
  • ENSP00000288955
  • ENST00000356046
  • ENSP00000348333
  • ENST00000361548
  • ENSP00000354943

Symbol
  • SOM
  • TFCP2L4
  • SOM
  • VWS2
  • TFCP2L4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.82
biological process
0.78
tissue sample
0.71
gene perturbation
0.62
PubMedID
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.95   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.95   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (47)
1 – 10 of 47
VSIG8
Tdark
Novelty: 1.45341615
p_int: 0.861126681
p_ni: 0.138873143
p_wrong: 1.76e-7
Score: 0.39
Data Source: BioPlex,STRINGDB
IRF6
Tbio
Family: TF
Novelty: 0.00079423
Score: 0.788
Data Source: STRINGDB
ZNF750
Tbio
Novelty: 0.06582947
Score: 0.7
Data Source: STRINGDB
MTHFD2L
Tdark
Family: Enzyme
Novelty: 0.27741083
Score: 0.668
Data Source: STRINGDB
OVOL1
Tbio
Family: TF
Novelty: 0.07964392
Score: 0.621
Data Source: STRINGDB
RIPK4
Tchem
Family: Kinase
Novelty: 0.00970161
Score: 0.62
Data Source: STRINGDB
KRT4
Tbio
Novelty: 0.00704461
Score: 0.608
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.0001303
Score: 0.606
Data Source: STRINGDB
TAF8
Tbio
Novelty: 0.00733106
Score: 0.552
Data Source: STRINGDB
TGM1
Tchem
Family: Enzyme
Novelty: 0.00190135
Score: 0.546
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.95

PubMed score by year
PubTator Score  41.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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