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Tbio
WDR66
Cilia- and flagella-associated protein 251

Protein Summary
Description
May regulate cilium motility through its role in the assembly of the axonemal radial spokes. This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member appears to function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated with variance in MPV. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288912
  • ENSP00000288912
  • ENSG00000158023
  • ENST00000397454
  • ENSP00000380595

Symbol
  • CFAP251
  • SPGF33
  • CFAP251
  • CaM-IP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.66
histone modification site profile
0.61
trait
0.61
tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.64   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.64   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
3
7
99.2
blood metabolite measurement
1
1
1
67.5
C-reactive protein measurement
1
1
1
65.2
alcohol abuse
2
1
2
58
liver fibrosis measurement
2
1
2
58
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
99.2
blood metabolite measurement
1
67.5
C-reactive protein measurement
1
65.2
alcohol abuse
2
58
liver fibrosis measurement
2
58
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (30)
1 – 10 of 30
CFAP61
Tdark
Novelty: 0.58493403
Score: 0.893
Data Source: STRINGDB
MAATS1
Tbio
Novelty: 0.17802223
Score: 0.891
Data Source: STRINGDB
RSPH3
Tdark
Novelty: 0.04470453
Score: 0.791
Data Source: STRINGDB
TBPL2
Tbio
Novelty: 0.01299173
Score: 0.755
Data Source: STRINGDB
DNAH6
Tdark
Novelty: 0.18343511
Score: 0.749
Data Source: STRINGDB
DNAH3
Tdark
Novelty: 0.0628368
Score: 0.728
Data Source: STRINGDB
DNALI1
Tbio
Novelty: 0.13865981
Score: 0.717
Data Source: STRINGDB
TMCC2
Tdark
Novelty: 0.21581357
Score: 0.649
Data Source: STRINGDB
AKAP10
Tbio
Family: Enzyme
Novelty: 0.03517248
Score: 0.623
Data Source: STRINGDB
CCDC40
Tbio
Novelty: 0.06726469
Score: 0.615
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.64

PubMed score by year
PubTator Score  3.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer