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Tbio
DRC1
Dynein regulatory complex protein 1

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437). This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288710
  • ENSP00000288710
  • ENSG00000157856

Symbol
  • C2orf39
  • CCDC164
  • CILD21
  • C2orf39
  • CCDC164
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.6
histone modification site profile
0.57
tissue
0.54
cell line
0.46
phenotype
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.64   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.64   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (65)
1 – 10 of 65
CCDC65
Tdark
Novelty: 0.05107666
Score: 0.924
Data Source: STRINGDB
CCDC40
Tbio
Novelty: 0.06726469
Score: 0.882
Data Source: STRINGDB
CCDC39
Tbio
Novelty: 0.0150835
Score: 0.852
Data Source: STRINGDB
CCDC114
Tbio
Novelty: 0.12534741
Score: 0.757
Data Source: STRINGDB
DNAH11
Tbio
Novelty: 0.02448234
Score: 0.733
Data Source: STRINGDB
GAS8
Tbio
Novelty: 0.03540885
Score: 0.732
Data Source: STRINGDB
RSPH4A
Tbio
Novelty: 0.07992083
Score: 0.728
Data Source: STRINGDB
ARMC4
Tbio
Novelty: 0.17860406
Score: 0.727
Data Source: STRINGDB
LRRC6
Tbio
Novelty: 0.10994386
Score: 0.72
Data Source: STRINGDB
ZMYND10
Tbio
Novelty: 0.05524895
Score: 0.719
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.64

PubMed score by year
PubTator Score  32.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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