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Tbio
DPYSL5
Dihydropyrimidinase-related protein 5

Protein Summary
Description
May have a function in neuronal differentiation and/or axon growth. This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288699
  • ENSP00000288699
  • ENSG00000157851
  • ENST00000401478
  • ENSP00000385549
  • ENST00000614712
  • ENSP00000481305

Symbol
  • CRMP5
  • ULIP6
  • CRAM
  • CRMP5
  • Ulip6
  • CRMP-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
microRNA
0.68
histone modification site profile
0.66
PubMedID
0.58
transcription factor
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.68   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.68   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fasting blood glucose measurement
2
1
2
64.4
cortical thickness
1
1
1
60.2
body mass index
1
1
1
60.2
C-reactive protein measurement
1
1
1
56.9
cognitive function measurement
1
1
1
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fasting blood glucose measurement
2
64.4
cortical thickness
1
60.2
body mass index
1
60.2
C-reactive protein measurement
1
56.9
cognitive function measurement
1
45.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase like 5
VGNC:227
459088
Macaque
dihydropyrimidinase like 5
699648
Mouse
MGI:1929772
65254
Rat
RGD:620467
65208
Dog
dihydropyrimidinase like 5
VGNC:40085
483004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase like 5
Macaque
dihydropyrimidinase like 5
Mouse
Rat
Dog
dihydropyrimidinase like 5
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BPU6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
Semaphorin interactions
Protein-Protein Interactions (77)
1 – 10 of 77
DPYSL3
Tbio
Family: Enzyme
Novelty: 0.01284077
p_int: 0.999999958
p_ni: 4.2e-8
Score: 0.985
Data Source: BioPlex,STRINGDB
DPYSL4
Tbio
Family: Enzyme
Novelty: 0.0449179
p_int: 0.999999153
p_ni: 8.47e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
DPYSL2
Tbio
Family: Enzyme
Novelty: 0.00374969
p_int: 0.999995026
p_ni: 0.000004974
Score: 0.986
Data Source: BioPlex,STRINGDB
DPYS
Tbio
Family: Enzyme
Novelty: 0.01272377
p_int: 0.999602053
p_ni: 0.000397947
Score: 0.876
Data Source: BioPlex,STRINGDB
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.99863412
p_ni: 0.00136588
Data Source: BioPlex
LONRF2
Tdark
Family: Enzyme
Novelty: 1.01811251
p_int: 0.998115835
p_ni: 0.001855099
p_wrong: 0.000029066
Score: 0.265
Data Source: BioPlex,STRINGDB
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.997484938
p_ni: 0.002515062
Data Source: BioPlex
LGALS7
Tbio
Novelty: 0.00753996
p_int: 0.995252467
p_ni: 0.004747533
Score: 0.489
Data Source: BioPlex,STRINGDB
TGIF2LY
Tdark
Family: TF
p_int: 0.987835639
p_ni: 0.012164361
Data Source: BioPlex
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
p_int: 0.987704676
p_ni: 0.012295324
Score: 0.312
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  180.68

PubMed score by year
PubTator Score  103.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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