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Tbio
SPPL3
Signal peptide peptidase-like 3

Protein Summary
Description
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353487
  • ENSP00000288680
  • ENSG00000157837

Symbol
  • IMP2
  • PSL4
  • IMP2
  • PSH1
  • PSL4
  • PRO4332
  • MDHV1887
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
kinase perturbation
0.95
disease perturbation
0.87
microRNA
0.83
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.54   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.54   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
2
2
0
3.3
97.5
C-reactive protein measurement
1
1
1
95.9
self reported educational attainment
1
1
1
86.1
mathematical ability
1
1
1
85.2
3
2
0
1
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
3.3
97.5
C-reactive protein measurement
1
95.9
self reported educational attainment
1
86.1
mathematical ability
1
85.2
0
1
84.7
Protein-Protein Interactions (55)
1 – 10 of 55
CHRND
Tclin
Family: IC
Novelty: 0.0441685
p_int: 0.991552264
p_ni: 0.008419354
p_wrong: 0.000028382
Data Source: BioPlex
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.980121751
p_ni: 0.019546051
p_wrong: 0.000332198
Score: 0.152
Data Source: BioPlex,STRINGDB
SLC2A12
Tbio
Family: Transporter
Novelty: 0.01455533
p_int: 0.96688768
p_ni: 0.033067617
p_wrong: 0.000044703
Data Source: BioPlex
SLC9A8
Tbio
Family: Transporter
Novelty: 0.03305341
p_int: 0.955397054
p_ni: 0.0363581
p_wrong: 0.008244846
Data Source: BioPlex
SPPL2B
Tbio
Family: Enzyme
Novelty: 0.0274774
p_int: 0.951277165
p_ni: 0.048722835
Score: 0.407
Data Source: BioPlex,STRINGDB
SLC6A15
Tchem
Family: Transporter
Novelty: 0.04011524
p_int: 0.92322051
p_ni: 0.076778142
p_wrong: 0.000001349
Data Source: BioPlex
SLC7A14
Tbio
Family: Transporter
Novelty: 0.1613451
p_int: 0.916618318
p_ni: 0.072881635
p_wrong: 0.010500046
Data Source: BioPlex
ADGRG5
Tdark
Family: GPCR
Novelty: 0.26575982
p_int: 0.9131929
p_ni: 0.080127386
p_wrong: 0.006679714
Data Source: BioPlex
P2RX2
Tchem
Family: IC
Novelty: 0.00241146
p_int: 0.896120031
p_ni: 0.103713378
p_wrong: 0.00016659
Data Source: BioPlex
HTR3A
Tclin
Family: IC
Novelty: 0.00217443
p_int: 0.894842245
p_ni: 0.103034301
p_wrong: 0.002123454
Data Source: BioPlex
Publication Statistics
PubMed Score  40.54

PubMed score by year
PubTator Score  11.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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