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Tclin
BRAF
Serine/threonine-protein kinase B-raf

Protein Summary
Description
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this g ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
hub protein
0.99
protein domain
0.99
transcription factor perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.75   (req: < 5)
Gene RIFs: 1893   (req: <= 3)
Antibodies: 2018   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.75   (req: >= 5)
Gene RIFs: 1893   (req: > 3)
Antibodies: 2018   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1480
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1.1
81.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
81.3
Protein Data Bank (69)
1 – 5 of 69
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (170)
ARMS-mediated activation (R-HSA-170984)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARMS-mediated activation
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
ARMS-mediated activation
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Gene Ontology Terms (52)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (187)
1 – 10 of 187
MAP2K1
Tclin
Family: Kinase
Novelty: 0.0005278
p_int: 0.999999989
p_ni: 9e-9
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RAB3GAP1
Tbio
Family: Enzyme
Novelty: 0.0286836
p_int: 0.999999923
p_ni: 7.7e-8
Score: 0.156
Data Source: BioPlex,STRINGDB
MAP2K2
Tclin
Family: Kinase
Novelty: 0.00706525
p_int: 0.999999838
p_ni: 1.62e-7
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
p_int: 0.999983793
p_ni: 1.04e-7
p_wrong: 0.000016103
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
p_int: 0.999978354
p_ni: 0.000021646
Score: 0.978
Data Source: BioPlex,STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00117121
p_int: 0.999973271
p_ni: 0.000026729
Score: 0.952
Data Source: BioPlex,Reactome,STRINGDB
DELE1
Tbio
Novelty: 0.096403
p_int: 0.999942984
p_ni: 0.000004487
p_wrong: 0.000052529
Score: 0.28
Data Source: BioPlex,STRINGDB
ARAF
Tchem
Family: Kinase
Novelty: 0.00432488
p_int: 0.999791505
p_ni: 0.000208495
Score: 0.952
Data Source: BioPlex,Reactome,STRINGDB
FKBPL
Tbio
Novelty: 0.02054842
p_int: 0.999448956
p_ni: 0.000551004
p_wrong: 3.9e-8
Score: 0.23
Data Source: BioPlex,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
p_int: 0.998682404
p_ni: 0.001317591
p_wrong: 5e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  457.75

PubMed score by year
PubTator Score  5924.6

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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