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Tbio
ERC2
ERC protein 2

Protein Summary
Description
Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regulators of neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288221
  • ENSP00000288221
  • ENSG00000187672
  • ENST00000460849
  • ENSP00000417445
  • ENST00000612797
  • ENSP00000483127

Symbol
  • KIAA0378
  • CAST
  • CAST1
  • ELKSL
  • Spc110
  • SPBC110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
microRNA
0.76
tissue sample
0.74
disease
0.61
interacting protein
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.49   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.49   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
6
11
97.5
smoking status measurement
2
1
2
75.5
body mass index
2
1
2
71.5
hip bone size
1
1
1
69
intertrochanteric region size
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
11
97.5
smoking status measurement
2
75.5
body mass index
2
71.5
hip bone size
1
69
intertrochanteric region size
1
59
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELKS/RAB6-interacting/CAST family member 2
VGNC:10478
460460
Macaque
ELKS/RAB6-interacting/CAST family member 2
705338
Mouse
MGI:1098749
238988
Rat
RGD:708372
259269
Dog
ELKS/RAB6-interacting/CAST family member 2
VGNC:40440
484720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELKS/RAB6-interacting/CAST family member 2
Macaque
ELKS/RAB6-interacting/CAST family member 2
Mouse
Rat
Dog
ELKS/RAB6-interacting/CAST family member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15083-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (70)
1 – 10 of 70
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.789595292
p_ni: 0.000162463
p_wrong: 0.210242245
Score: 0.241
Data Source: BioPlex,STRINGDB
RIMS1
Tbio
Novelty: 0.01126545
Score: 0.843
Data Source: STRINGDB
BSN
Tbio
Novelty: 0.00468806
Score: 0.799
Data Source: STRINGDB
TUBGCP2
Tbio
Novelty: 0.01856674
Score: 0.793
Data Source: STRINGDB
UNC13A
Tbio
Novelty: 0.01009835
Score: 0.774
Data Source: STRINGDB
PPFIA1
Tbio
Novelty: 0.01904029
Score: 0.766
Data Source: STRINGDB
PPFIA3
Tbio
Novelty: 0.03837299
Score: 0.765
Data Source: STRINGDB
PCLO
Tbio
Novelty: 0.00918397
Score: 0.733
Data Source: STRINGDB
PCNT
Tbio
Novelty: 0.00369505
Score: 0.719
Data Source: STRINGDB
PRR16
Tdark
Novelty: 0.17809341
Score: 0.711
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.49

PubMed score by year
PubTator Score  11.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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