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Tclin
KIT
Mast/stem cell growth factor receptor Kit

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288135
  • ENSP00000288135
  • ENSG00000157404
  • ENST00000412167
  • ENSP00000390987

Symbol
  • SCFR
  • PBT
  • SCFR
  • C-Kit
  • CD117
  • MASTC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
PubMedID
1
hub protein
0.99


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9213.59   (req: < 5)
Gene RIFs: 859   (req: <= 3)
Antibodies: 4953   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9213.59   (req: >= 5)
Gene RIFs: 859   (req: > 3)
Antibodies: 4953   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 88
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 377
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
74.7
neutrophil percentage of leukocytes
1
1
1
42.2
body height
1
1
1
37.7
high density lipoprotein cholesterol measurement
1
1
1
32
triglyceride measurement
1
1
1
30.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
74.7
neutrophil percentage of leukocytes
1
42.2
body height
1
37.7
high density lipoprotein cholesterol measurement
1
32
triglyceride measurement
1
30.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KIT proto-oncogene receptor tyrosine kinase
VGNC:6662
461316
Mouse
MGI:96677
16590
Rat
RGD:620568
64030
Dog
KIT proto-oncogene receptor tyrosine kinase
VGNC:42422
403811
Horse
KIT proto-oncogene receptor tyrosine kinase
VGNC:19433
100009704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KIT proto-oncogene receptor tyrosine kinase
Mouse
Rat
Dog
KIT proto-oncogene receptor tyrosine kinase
Horse
KIT proto-oncogene receptor tyrosine kinase
Protein Data Bank (21)
1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (65)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Gene Ontology Terms (98)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (517)
1 – 10 of 517
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.999913862
p_ni: 1.3e-7
p_wrong: 0.000086008
Score: 0.56
Data Source: BioPlex,STRINGDB
KITLG
Tbio
Novelty: 0.00036337
Score: 0.999
Data Source: Reactome,STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.981
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.98
Data Source: Reactome,STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.98
Data Source: Reactome,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.976
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.974
Data Source: Reactome,STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.973
Data Source: STRINGDB
SOCS6
Tbio
Novelty: 0.00993375
Score: 0.972
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.972
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  9213.59

PubMed score by year
PubTator Score  4277.43

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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